Old Drugs for New Indications in Cardiovascular Medicine

Yaron Arbel, Wael Abuzeid, Robert S. Rosenson, Alanna Weisman, Michael E. Farkouh

Research output: Contribution to journalReview articlepeer-review


Inflammation participates in the initiation and progression of atherosclerotic cardiovascular disease, and it is a critical inciting factor leading to acute ischemic events. Evidence has shown that certain anti-inflammatory medications used to treat non-atherosclerotic inflammatory diseases reduce cardiovascular events. This article reviews evidence that commonly used anti-inflammatory therapies (colchicine, allopurinol, methotrexate), reduce cardiovascular events. We discuss potential mechanisms of action, efficacy, and safety of these therapies and propose a clinical trials design to investigate their efficacy.

Original languageEnglish
Pages (from-to)223-232
Number of pages10
JournalCardiovascular Drugs and Therapy
Issue number2
StatePublished - 1 Apr 2018


  • Allopurinol
  • Atherosclerosis
  • Cardiovascular disease
  • Colchicine
  • Inflammation
  • Methotrexate


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