TY - JOUR
T1 - Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset
AU - Ostrovsky, Michael
AU - Rosenblatt, Amir
AU - Iriqat, Salam
AU - Shteiwi, Abdallah
AU - Sharon, Yael
AU - Kramer, Michal
AU - Vishnevskia-Dai, Vicktoria
AU - Sar, Shaul
AU - Boulos, Yosif
AU - Tomkins-Netzer, Oren
AU - Lavee, Natalie
AU - Ben-Arie-Weintrob, Yael
AU - Pizem, Hadas
AU - Hareuveni-Blum, Tamar
AU - Schneck, Marina
AU - Gepstein, Raz
AU - Masarwa, Dua
AU - Nakhoul, Nakhoul
AU - Bakshi, Erez
AU - Shulman, Shiri
AU - Goldstein, Michaella
AU - Ramon, Dan
AU - Anouk, Marina
AU - Habot-Wilner, Zohar
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/2
Y1 - 2023/2
N2 - Behçet disease (BD) is a multisystemic disease that commonly involves the eyes. Although it affects patients in all age groups, data on ocular disease by age of onset are limited. This retrospective, multicenter study aimed to compare epidemiology, systemic and ocular manifestations, treatments and outcomes between three age groups: juvenile (<18 years), adult (18–39 years) and late (≥40 years) disease onset. The study included 175 ocular BD patients (303 eyes) from Israel and Palestine: juvenile-onset (n = 25, 14.3%), adult-onset (n = 120, 68.6%) and late-onset (n = 30, 17.1%). Most patients in all groups were male. Systemic manifestations were similar in all groups. Systemic co-morbidities were more common in late-onset patients. Bilateral panuveitis was the most common ocular manifestation in all patients. Non-occlusive retinal vasculitis, peripheral vessel occlusions, cataract and elevated intraocular pressure were found more commonly among juvenile-onset eyes. Anterior uveitis and macular ischemia were most common among late-onset eyes, while branch retinal vein occlusion was most common in adult and late-onset eyes. All patients were treated with corticosteroids. Methotrexate, immunomodulatory combinations and biologic treatments were more commonly used for juvenile-onset patients. All groups had a similar visual outcome. Our study showed that patients with ocular BD have varied ocular manifestations and require different treatments according to age of disease onset, but visual outcome is similar.
AB - Behçet disease (BD) is a multisystemic disease that commonly involves the eyes. Although it affects patients in all age groups, data on ocular disease by age of onset are limited. This retrospective, multicenter study aimed to compare epidemiology, systemic and ocular manifestations, treatments and outcomes between three age groups: juvenile (<18 years), adult (18–39 years) and late (≥40 years) disease onset. The study included 175 ocular BD patients (303 eyes) from Israel and Palestine: juvenile-onset (n = 25, 14.3%), adult-onset (n = 120, 68.6%) and late-onset (n = 30, 17.1%). Most patients in all groups were male. Systemic manifestations were similar in all groups. Systemic co-morbidities were more common in late-onset patients. Bilateral panuveitis was the most common ocular manifestation in all patients. Non-occlusive retinal vasculitis, peripheral vessel occlusions, cataract and elevated intraocular pressure were found more commonly among juvenile-onset eyes. Anterior uveitis and macular ischemia were most common among late-onset eyes, while branch retinal vein occlusion was most common in adult and late-onset eyes. All patients were treated with corticosteroids. Methotrexate, immunomodulatory combinations and biologic treatments were more commonly used for juvenile-onset patients. All groups had a similar visual outcome. Our study showed that patients with ocular BD have varied ocular manifestations and require different treatments according to age of disease onset, but visual outcome is similar.
KW - Behçet disease
KW - Behçet uveitis
KW - adult-onset Behçet disease
KW - juvenile-onset Behçet disease
KW - late-onset Behçet disease
KW - ocular Behçet disease
KW - uveitis
UR - http://www.scopus.com/inward/record.url?scp=85148851434&partnerID=8YFLogxK
U2 - 10.3390/biomedicines11020624
DO - 10.3390/biomedicines11020624
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C2 - 36831160
AN - SCOPUS:85148851434
SN - 2227-9059
VL - 11
JO - Biomedicines
JF - Biomedicines
IS - 2
M1 - 624
ER -