Occurrence of Parkinson's syndrome in type I Gaucher disease

O. Neudorfer, N. Giladi, D. Elstein, A. Abrahamov, T. Turezkite, E. Achai, A. Reches, B. Bembi, A. Zimran

Research output: Contribution to journalArticlepeer-review

Abstract

Gaucher disease, the most prevalent glycolipid storage disorder, is classically subdivided into types according to the presence or absence of neurological involvement. Type I has hitherto been considered non-neuronopathic. We present six cases and a review of the literature of Parkinsonian symptoms in type I Gaucher disease patients. The hallmark of this atypical Parkinsonian syndrome is a relatively severe clinical course with early appearance of neurological signs in the 4th to 6th decade of life, aggressive progression of the signs and refractoriness to conventional anti-Parkinson therapy. We discuss the implications of these findings in the light of enzyme replacement therapy for Gaucher disease.

Original languageEnglish
Pages (from-to)691-694
Number of pages4
JournalQJM - Monthly Journal of the Association of Physicians
Volume89
Issue number9
StatePublished - Sep 1996
Externally publishedYes

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