Occurrence of fatigue over 20 years after recovery from Guillain-Barré syndrome

Vivian E. Drory*, Tanja Bronipolsky, Vadim Bluvshtein, Amiram Catz, Amos D. Korczyn

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Introduction: Reports regarding outcome of Guillain-Barré syndrome (GBS) are usually limited to relatively short follow-up. We assessed the occurrence of fatigue and correlated it to clinical measures in patients who had suffered from GBS over 20 years previously. Methods: We contacted 24 patients with GBS requiring in-hospital rehabilitation during the years 1970-1987. Disability was established at rehabilitation admission using the Hughes scale (HS). Disability and fatigue were assessed at time of this study by the Overall Disability Sum Score (ODSS) and the Fatigue Severity Scale (FSS). Results: Mean HS at admission was 2.5 ± 0.7, and at follow-up 1.1 ± 1.3. Mean ODSS was 2.8 ± 3.6, FSS was 4.4 ± 2. Ten patients reported severe fatigue (> 5). Very good correlations were found between FSS and HS at admission and follow-up and between FSS and ODSS. FSS was not influenced by patients' age, age at disease onset, gender or time from GBS to the study. Conclusion: Fatigue can persist after apparent recovery from GBS and remain severe for many years.

Original languageEnglish
Pages (from-to)72-75
Number of pages4
JournalJournal of the Neurological Sciences
Issue number1-2
StatePublished - 15 May 2012


  • Disability
  • Fatigue
  • Guillain-Barre-syndrome
  • Natural history
  • Prognosis


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