Occurrence of alkaline phosphatase-positive fibers in experimental muscle disorders

Menachem Sadeh, Anna M. Kaminska, Pushbah Deshmukh, Lawrence Z. Stern

Research output: Contribution to journalArticlepeer-review


The alkaline phosphatase (AP) reaction was carried out on muscle sections from a large series of rats under various experimental neuromuscular disorders. Only denervated and non-innervated muscle fibers stained positively with the AP reaction. In other conditions including degenerating, regenerating, tenotomized and immature muscles the AP reaction was negative. This suggests that the presence of AP-positive fibers in human neuromuscular disorders reflects a concomitant denervation process.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalJournal of the Neurological Sciences
Issue number2-3
StatePublished - Dec 1986
Externally publishedYes


  • Alkaline phosphatase
  • Denervation
  • Muscle fiber regeneration
  • Muscle histochemistry


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