TY - JOUR
T1 - Occupational solvent exposure and risk of glioma in the INTEROCC study
AU - Benke, Geza
AU - Turner, Michelle C.
AU - Fleming, Sarah
AU - Figuerola, Jordi
AU - Kincl, Laurel
AU - Richardson, Lesley
AU - Blettner, Maria
AU - Hours, Martine
AU - Krewski, Daniel
AU - McLean, David
AU - Parent, Marie Elise
AU - Sadetzki, Siegal
AU - Schlaefer, Klaus
AU - Schlehofer, Brigitte
AU - Siemiatycki, Jack
AU - Van Tongeren, Martie
AU - Cardis, Elisabeth
N1 - Publisher Copyright:
© 2017 Cancer Research UK. All rights reserved.
PY - 2017/10/10
Y1 - 2017/10/10
N2 - Background:The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade.Methods:Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM.Results:Analysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74-1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour.Conclusions:The results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.
AB - Background:The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade.Methods:Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM.Results:Analysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74-1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour.Conclusions:The results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.
UR - http://www.scopus.com/inward/record.url?scp=85028346856&partnerID=8YFLogxK
U2 - 10.1038/bjc.2017.285
DO - 10.1038/bjc.2017.285
M3 - מאמר
C2 - 28910824
AN - SCOPUS:85028346856
VL - 117
SP - 1246
EP - 1254
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 8
ER -
