TY - JOUR
T1 - Occupational exposure to extremely low-frequency magnetic fields and brain tumor risks in the INTEROCC study
AU - Turner, Michelle C.
AU - Benke, Geza
AU - Bowman, Joseph D.
AU - Figuerola, Jordi
AU - Fleming, Sarah
AU - Hours, Martine
AU - Kincl, Laurel
AU - Krewski, Daniel
AU - McLean, Dave
AU - Parent, Marie Elise
AU - Richardson, Lesley
AU - Sadetzki, Siegal
AU - Schlaefer, Klaus
AU - Schlehofer, Brigitte
AU - Schüz, Joachim
AU - Siemiatycki, Jack
AU - Van Tongeren, Martie
AU - Cardis, Elisabeth
N1 - Publisher Copyright:
© 2014 AACR.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Methods: Cases of adult primary glioma and meningioma were recruited in seven countries (Australia, Canada, France, Germany, Israel, New Zealand, and the United Kingdom) between 2000 and 2004. Estimates of mean workday ELF exposure based on a job exposure matrix were assigned. Estimates of cumulative exposure, average exposure, maximumexposure, and exposure duration were calculated for the lifetime, and 1 to 4, 5 to 9, and 10+ years before the diagnosis/reference date.Results: There were 3, 761 included brain tumor cases (1, 939 glioma and 1, 822 meningioma) and 5, 404 population controls. There was no association between lifetime cumulative ELF exposure and glioma or meningioma risk. However, there were positive associations between cumulative ELF 1 to 4 years before the diagnosis/reference date and glioma [odds ratio (OR) ≥90th percentile vs. < 25th percentile, 1.67; 95% confidence interval (CI), 1.36-2.07; P Linear trend < 0.0001], and, somewhat weaker associations with meningioma (OR ≥90th percentile vs. < 25th percentile, 1.23; 95% CI, 0.97-1.57; P Linear trend = 0.02).Conclusions: Results showed positive associations between ELF in the recent past and glioma.Impact: Occupational ELF exposure may play a role in the later stages (promotion and progression) of brain tumorigenesis.Background: Occupational exposure to extremely low-frequency magnetic fields (ELF) is a suspected risk factor for brain tumors, however the literature is inconsistent. Few studies have assessed whether ELF in different time windows of exposure maybe associated with specific histologic types of brain tumors. This study examines the association between ELF and brain tumors in the large-scale INTEROCC study.
AB - Methods: Cases of adult primary glioma and meningioma were recruited in seven countries (Australia, Canada, France, Germany, Israel, New Zealand, and the United Kingdom) between 2000 and 2004. Estimates of mean workday ELF exposure based on a job exposure matrix were assigned. Estimates of cumulative exposure, average exposure, maximumexposure, and exposure duration were calculated for the lifetime, and 1 to 4, 5 to 9, and 10+ years before the diagnosis/reference date.Results: There were 3, 761 included brain tumor cases (1, 939 glioma and 1, 822 meningioma) and 5, 404 population controls. There was no association between lifetime cumulative ELF exposure and glioma or meningioma risk. However, there were positive associations between cumulative ELF 1 to 4 years before the diagnosis/reference date and glioma [odds ratio (OR) ≥90th percentile vs. < 25th percentile, 1.67; 95% confidence interval (CI), 1.36-2.07; P Linear trend < 0.0001], and, somewhat weaker associations with meningioma (OR ≥90th percentile vs. < 25th percentile, 1.23; 95% CI, 0.97-1.57; P Linear trend = 0.02).Conclusions: Results showed positive associations between ELF in the recent past and glioma.Impact: Occupational ELF exposure may play a role in the later stages (promotion and progression) of brain tumorigenesis.Background: Occupational exposure to extremely low-frequency magnetic fields (ELF) is a suspected risk factor for brain tumors, however the literature is inconsistent. Few studies have assessed whether ELF in different time windows of exposure maybe associated with specific histologic types of brain tumors. This study examines the association between ELF and brain tumors in the large-scale INTEROCC study.
UR - http://www.scopus.com/inward/record.url?scp=84907183840&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-14-0102
DO - 10.1158/1055-9965.EPI-14-0102
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C2 - 24935666
AN - SCOPUS:84907183840
SN - 1055-9965
VL - 23
SP - 1863
EP - 1872
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 9
ER -