TY - JOUR
T1 - Obsessive-compulsive disorder patients display enhanced latent inhibition on a visual search task
AU - Kaplan, Oren
AU - Dar, Reuven
AU - Rosenthal, Lirona
AU - Hermesh, Haggai
AU - Fux, Mendel
AU - Lubow, R. E.
N1 - Funding Information:
The writing of this paper was supported by a grant from The Israel Science Foundation funded by the Israel Academy of Sciences and Humanities.
PY - 2006/8
Y1 - 2006/8
N2 - Latent inhibition (LI) is a phenomenon that reflects the ability to ignore irrelevant stimuli. LI is attenuated in some schizophrenic patient groups and in high schizotypal normal participants. One study has found enhanced LI in patients with obsessive-compulsive disorder (OCD [Swerdlow, N. R., Hartston, H. J., & Hartman, P. L., 1999. Enhanced visual latent inhibition in obsessive-compulsive disorder. Biological Psychiatry, 45, 482-488]). The present experiment replicated this finding using a within-subject visual search LI task, with OCD patients displaying more LI than healthy controls. The contrasting LI effects in schizophrenia and OCD are discussed in terms of how these groups differentially process relevant and irrelevant stimuli, and how that outcome affects subsequent behavior.
AB - Latent inhibition (LI) is a phenomenon that reflects the ability to ignore irrelevant stimuli. LI is attenuated in some schizophrenic patient groups and in high schizotypal normal participants. One study has found enhanced LI in patients with obsessive-compulsive disorder (OCD [Swerdlow, N. R., Hartston, H. J., & Hartman, P. L., 1999. Enhanced visual latent inhibition in obsessive-compulsive disorder. Biological Psychiatry, 45, 482-488]). The present experiment replicated this finding using a within-subject visual search LI task, with OCD patients displaying more LI than healthy controls. The contrasting LI effects in schizophrenia and OCD are discussed in terms of how these groups differentially process relevant and irrelevant stimuli, and how that outcome affects subsequent behavior.
KW - Anxiety
KW - Attention
KW - Latent inhibition
KW - Obsessive-compulsive disorder (OCD)
KW - Schizophrenia
KW - Visual search
UR - http://www.scopus.com/inward/record.url?scp=33745441458&partnerID=8YFLogxK
U2 - 10.1016/j.brat.2005.09.005
DO - 10.1016/j.brat.2005.09.005
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AN - SCOPUS:33745441458
SN - 0005-7967
VL - 44
SP - 1137
EP - 1145
JO - Behaviour Research and Therapy
JF - Behaviour Research and Therapy
IS - 8
ER -