TY - JOUR
T1 - Objective versus subjective assessment of methylphenidate response
AU - Manor, Iris
AU - Meidad, Sheera
AU - Zalsman, Gil
AU - Zemishlany, Zvi
AU - Tyano, Shmuel
AU - Weizman, Avraham
PY - 2008/9
Y1 - 2008/9
N2 - Subjective improvement-assessment in attention deficit/hyperactivity disorder (ADHD), following a single dose of methylphenidate (MPH) was compared to performance on the Test-of-Variables-of-Attention (TOVA). Self-perception was assessed with the clinical-global-impression-of-change (CGI-C). Participants included 165 ADHD subjects (M:F ratio 67%:33%) aged 5-18 (11.09 ± 3.43) years. TOVA was administered before and after MPH challenge (0.3 mg/kg). Self-perception CGI-C scores were compared to the TOVA scores. An inverse correlation was found only between CGI-C and the TOVA-Commission-scores (r = -0.326, p < 0.001). We thus conclude that subjective reports are too unreliable to be used in order to assess MPH benefit in ADHD pediatric populations.
AB - Subjective improvement-assessment in attention deficit/hyperactivity disorder (ADHD), following a single dose of methylphenidate (MPH) was compared to performance on the Test-of-Variables-of-Attention (TOVA). Self-perception was assessed with the clinical-global-impression-of-change (CGI-C). Participants included 165 ADHD subjects (M:F ratio 67%:33%) aged 5-18 (11.09 ± 3.43) years. TOVA was administered before and after MPH challenge (0.3 mg/kg). Self-perception CGI-C scores were compared to the TOVA scores. An inverse correlation was found only between CGI-C and the TOVA-Commission-scores (r = -0.326, p < 0.001). We thus conclude that subjective reports are too unreliable to be used in order to assess MPH benefit in ADHD pediatric populations.
KW - Attention
KW - Attention deficit hyperactivity disorder (ADHD)
KW - Continuous Performance Test (CPT)
KW - Methylphenidate (MPH)
KW - Self-perception
UR - http://www.scopus.com/inward/record.url?scp=45449105852&partnerID=8YFLogxK
U2 - 10.1007/s10578-007-0087-0
DO - 10.1007/s10578-007-0087-0
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C2 - 18058019
AN - SCOPUS:45449105852
SN - 0009-398X
VL - 39
SP - 273
EP - 282
JO - Child Psychiatry and Human Development
JF - Child Psychiatry and Human Development
IS - 3
ER -