Objective versus subjective assessment of methylphenidate response

Iris Manor*, Sheera Meidad, Gil Zalsman, Zvi Zemishlany, Shmuel Tyano, Avraham Weizman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Subjective improvement-assessment in attention deficit/hyperactivity disorder (ADHD), following a single dose of methylphenidate (MPH) was compared to performance on the Test-of-Variables-of-Attention (TOVA). Self-perception was assessed with the clinical-global-impression-of-change (CGI-C). Participants included 165 ADHD subjects (M:F ratio 67%:33%) aged 5-18 (11.09 ± 3.43) years. TOVA was administered before and after MPH challenge (0.3 mg/kg). Self-perception CGI-C scores were compared to the TOVA scores. An inverse correlation was found only between CGI-C and the TOVA-Commission-scores (r = -0.326, p < 0.001). We thus conclude that subjective reports are too unreliable to be used in order to assess MPH benefit in ADHD pediatric populations.

Original languageEnglish
Pages (from-to)273-282
Number of pages10
JournalChild Psychiatry and Human Development
Issue number3
StatePublished - Sep 2008


  • Attention
  • Attention deficit hyperactivity disorder (ADHD)
  • Continuous Performance Test (CPT)
  • Methylphenidate (MPH)
  • Self-perception


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