TY - JOUR
T1 - Obesity-related correlation between C-reactive protein and the calculated 10-y Framingham Coronary Heart Disease Risk Score
AU - Rogowski, O.
AU - Shapira, I.
AU - Toker, S.
AU - Melamed, S.
AU - Shirom, A.
AU - Berliner, S.
AU - Zeltser, D.
PY - 2005/7
Y1 - 2005/7
N2 - OBJECTIVE: To clarify the role of body mass index (BMI, kg/m2) adjustment in predictive models for cardiovascular events that add high-sensitivity C-reactive protein (hs-CRP) to the 10-y Framingham Coronary Heart Disease Risk Score (FCRS). DESIGN: A cross-sectional study in a group of apparently healthy individuals. SUBJECTS: In all, 1512 apparently healthy individuals (955 men and 557 women) at a respective age of 49.7 ± 10.6 and 50.6 ± 9.6 y. RESULTS: The Pearson correlation between hs-CRP and the calculated 10-y FCRS was lower when adjusted for BMI. This reduction was especially noted in women where it dropped from 0.247 to 0.09. The dominant role of hs-CRP concentrations was also noted in a linear regression model, again, especially noted in women (drop of the standardized coefficient from 0.517 for BMI to 0.08 for the FCRS). CONCLUSION: The correlation between hs-CRP and the 10-y FCRS is partly related to the presence of obesity. We raise the possibility that the addition of BMI to the predictive model of FCRS might attenuate the cost-effectiveness of CRP measurements for this specific risk assessment.
AB - OBJECTIVE: To clarify the role of body mass index (BMI, kg/m2) adjustment in predictive models for cardiovascular events that add high-sensitivity C-reactive protein (hs-CRP) to the 10-y Framingham Coronary Heart Disease Risk Score (FCRS). DESIGN: A cross-sectional study in a group of apparently healthy individuals. SUBJECTS: In all, 1512 apparently healthy individuals (955 men and 557 women) at a respective age of 49.7 ± 10.6 and 50.6 ± 9.6 y. RESULTS: The Pearson correlation between hs-CRP and the calculated 10-y FCRS was lower when adjusted for BMI. This reduction was especially noted in women where it dropped from 0.247 to 0.09. The dominant role of hs-CRP concentrations was also noted in a linear regression model, again, especially noted in women (drop of the standardized coefficient from 0.517 for BMI to 0.08 for the FCRS). CONCLUSION: The correlation between hs-CRP and the 10-y FCRS is partly related to the presence of obesity. We raise the possibility that the addition of BMI to the predictive model of FCRS might attenuate the cost-effectiveness of CRP measurements for this specific risk assessment.
KW - 10-y calculated Framingham Heart Risk Score
KW - High-sensitivity C-reactive protein
UR - http://www.scopus.com/inward/record.url?scp=21244485061&partnerID=8YFLogxK
U2 - 10.1038/sj.ijo.0802939
DO - 10.1038/sj.ijo.0802939
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AN - SCOPUS:21244485061
SN - 0307-0565
VL - 29
SP - 772
EP - 777
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 7
ER -
