TY - JOUR
T1 - Obesity and obstructive sleep apnea in children
AU - Tauman, Riva
AU - Gozal, David
N1 - Funding Information:
Support: DG is supported by NIH Grant HL-65270, The Children's Foundation Endowment for Sleep Research, and the Commonwealth of Kentucky Research Challenge Trust Fund.
PY - 2006/12
Y1 - 2006/12
N2 - The prevalence and severity of obesity in children and adolescent is dramatically increasing worldwide with a corresponding increase in the prevalence of obesity-associated morbidities particularly those involving OSAS and metabolic and cardiovascular sequelae. Obstructive sleep apnea and obesity hypoventilation syndrome are important and serious consequences of obesity, and may in fact mediate components of the association between obesity and metabolic and cardiovascular morbidities, most likely via potentiation of inflammatory cascades. It is anticipated that the increased prevalence of obesity in children and adolescents in our society will be accompanied by a steady increase in the incidence of OSAS. In this review, we will examine our current understanding of sleep-disordered breathing and associated morbidities in obese children, and summarize the range of therapeutic modalities currently available for this high-risk population.
AB - The prevalence and severity of obesity in children and adolescent is dramatically increasing worldwide with a corresponding increase in the prevalence of obesity-associated morbidities particularly those involving OSAS and metabolic and cardiovascular sequelae. Obstructive sleep apnea and obesity hypoventilation syndrome are important and serious consequences of obesity, and may in fact mediate components of the association between obesity and metabolic and cardiovascular morbidities, most likely via potentiation of inflammatory cascades. It is anticipated that the increased prevalence of obesity in children and adolescents in our society will be accompanied by a steady increase in the incidence of OSAS. In this review, we will examine our current understanding of sleep-disordered breathing and associated morbidities in obese children, and summarize the range of therapeutic modalities currently available for this high-risk population.
KW - children
KW - obesity
KW - obesity-hypoventilation syndrome
KW - obstructive sleep apnoea
UR - http://www.scopus.com/inward/record.url?scp=33751089298&partnerID=8YFLogxK
U2 - 10.1016/j.prrv.2006.08.003
DO - 10.1016/j.prrv.2006.08.003
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C2 - 17098639
AN - SCOPUS:33751089298
SN - 1526-0542
VL - 7
SP - 247
EP - 259
JO - Paediatric Respiratory Reviews
JF - Paediatric Respiratory Reviews
IS - 4
ER -
