TY - JOUR
T1 - Nuttingins A-F and malonganenones D-H, tetraprenylated alkaloids from the tanzanian gorgonian Euplexaura nuttingi
AU - Sorek, Hagit
AU - Rudi, Amira
AU - Benayahu, Yehuda
AU - Ben-Califa, Nathalie
AU - Neumann, Drorit
AU - Kashman, Yoel
PY - 2007/7
Y1 - 2007/7
N2 - Six new tetraprenylated purine alkaloids, designated nuttingins A-F (1-6), were isolated together with three known malonganenones, A-C (12-14), and five new closely related malonganenones, D-H (7-11), from the gorgonian Euplexaura nuttingi collected in Pemba Island, Tanzania. The structures of the compounds were elucidated by interpretation of 1D and 2D NMR data including 15N chemical shifts obtained from 1H-15N HMBC spectra. Nuttingins A-E (1-5) and malonganenones D-G (7-10) displayed inhibitory activity against both K562 and UT7 tumor cell lines, compounds 3-5 being the most active ones, approximately 3-fold more potent than the others. Compounds 1-5 and 7-11 also induce apoptosis in transformed mammalian cells at a concentration of 1.25 μg/mL.
AB - Six new tetraprenylated purine alkaloids, designated nuttingins A-F (1-6), were isolated together with three known malonganenones, A-C (12-14), and five new closely related malonganenones, D-H (7-11), from the gorgonian Euplexaura nuttingi collected in Pemba Island, Tanzania. The structures of the compounds were elucidated by interpretation of 1D and 2D NMR data including 15N chemical shifts obtained from 1H-15N HMBC spectra. Nuttingins A-E (1-5) and malonganenones D-G (7-10) displayed inhibitory activity against both K562 and UT7 tumor cell lines, compounds 3-5 being the most active ones, approximately 3-fold more potent than the others. Compounds 1-5 and 7-11 also induce apoptosis in transformed mammalian cells at a concentration of 1.25 μg/mL.
UR - http://www.scopus.com/inward/record.url?scp=34548008830&partnerID=8YFLogxK
U2 - 10.1021/np060642l
DO - 10.1021/np060642l
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AN - SCOPUS:34548008830
SN - 0163-3864
VL - 70
SP - 1104
EP - 1109
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 7
ER -