Nuttingins A-F and malonganenones D-H, tetraprenylated alkaloids from the tanzanian gorgonian Euplexaura nuttingi

Hagit Sorek, Amira Rudi, Yehuda Benayahu, Nathalie Ben-Califa, Drorit Neumann, Yoel Kashman

Research output: Contribution to journalArticlepeer-review

Abstract

Six new tetraprenylated purine alkaloids, designated nuttingins A-F (1-6), were isolated together with three known malonganenones, A-C (12-14), and five new closely related malonganenones, D-H (7-11), from the gorgonian Euplexaura nuttingi collected in Pemba Island, Tanzania. The structures of the compounds were elucidated by interpretation of 1D and 2D NMR data including 15N chemical shifts obtained from 1H-15N HMBC spectra. Nuttingins A-E (1-5) and malonganenones D-G (7-10) displayed inhibitory activity against both K562 and UT7 tumor cell lines, compounds 3-5 being the most active ones, approximately 3-fold more potent than the others. Compounds 1-5 and 7-11 also induce apoptosis in transformed mammalian cells at a concentration of 1.25 μg/mL.

Original languageEnglish
Pages (from-to)1104-1109
Number of pages6
JournalJournal of Natural Products
Volume70
Issue number7
DOIs
StatePublished - Jul 2007

Fingerprint

Dive into the research topics of 'Nuttingins A-F and malonganenones D-H, tetraprenylated alkaloids from the tanzanian gorgonian Euplexaura nuttingi'. Together they form a unique fingerprint.

Cite this