Nucleophilicity of Some Reactivators of Phosphorylated Acetylcholinesterase1

Yacov Ashani, Sasson Cohen, Yacov Ashani, Sasson Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

A rational approach is presented toward the establishment of a structure-activity relationship in a series of reactivators of DFP-inhibited AChE. The value of kt, the first-order reactivation rate constant, at pH 7.4 is a function of both the nucleophilicity of the reactivator molecule and its basicity, reaching an optimum for compounds with a pKa value in the range 7.6-8.0.

Original languageEnglish
Pages (from-to)621-626
Number of pages6
JournalJournal of Medicinal Chemistry
Volume14
Issue number7
DOIs
StatePublished - 1 Jul 1971

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