Nucleolar organizer regions in breast cytology material

L. Rath-Wolfson, I. Hamel, M. Halpern, B. Klein, R. Gal*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To evaluate the presence of nucleolar organizer regions (NORs) by the argyrophil NOR (AgNOR) technique on scrape cytology on breast lumps. STUDY DESIGN: The study group consisted of 112 breast lumps that were sent for frozen section and included fibrocystic disease (52 cases), fibroadenomas (15 cases) and carcinomas (45 cases). Scrape cytology was performed on each case, and the number of AgNOR dots was recorded for 50 cells and the mean value calculated. RESULTS: The mean AgNOR counts were statistically significantly higher in malignant lesions in comparison to either fibroadenomas or fibrocystic changes. CONCLUSION: The AgNOR technique could be of use in cytologic material as an adjunct to fine needle aspiration of breast lesions.

Original languageEnglish
Pages (from-to)852-857
Number of pages6
JournalActa Cytologica
Issue number5
StatePublished - 1995
Externally publishedYes


  • breast neoplasms
  • nucleolus organizer region


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