Nuclear magnetic resonance parameters for monitoring coagulation of liver tissue

Dina Carasso; Uzi Eliav; Gil Navon

doi:10.1002/mrm.20693

Nuclear magnetic resonance parameters for monitoring coagulation of liver tissue

Dina Carasso, Uzi Eliav, Gil Navon^*

^*Corresponding author for this work

School of Chemistry

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A new NMR parameter is suggested as a sensitive tool for monitoring thermal coagulation of liver tissue. That parameter is the proton magnetization exchange time (τ_MEX) between water and the proteins. τ_MEX was very sensitive to coagulation and insensitive to temperature, therefore representing only damage to the tissue, independent of effects caused by temperature fluctuations. The measurement of τ_MEX by two different methods revealed the existence of two or more groups of proteins, characterized by their different transverse relaxation time, and τ_MEX.

Original language	English
Pages (from-to)	1082-1086
Number of pages	5
Journal	Magnetic Resonance in Medicine
Volume	54
Issue number	5
DOIs	https://doi.org/10.1002/mrm.20693
State	Published - Nov 2005

Keywords

Coagulation
Liver
NMR
Protein-water magnetization exchange
Thermal therapy

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AB - A new NMR parameter is suggested as a sensitive tool for monitoring thermal coagulation of liver tissue. That parameter is the proton magnetization exchange time (τMEX) between water and the proteins. τMEX was very sensitive to coagulation and insensitive to temperature, therefore representing only damage to the tissue, independent of effects caused by temperature fluctuations. The measurement of τMEX by two different methods revealed the existence of two or more groups of proteins, characterized by their different transverse relaxation time, and τMEX.

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KW - Liver

KW - NMR

KW - Protein-water magnetization exchange

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Nuclear magnetic resonance parameters for monitoring coagulation of liver tissue

Abstract

Keywords

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