Nuclear DNA content of the tall cell variant of papillary carcinoma of the thyroid gland

Yoram Stern*, Thomas Shpitzer, Ora Medelia, Raphael Feinmesser, Meora Feinmesser, Karl Segal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Tall cell carcinoma of the thyroid gland is an aggressive variant of papillary carcinoma. A high nuclear DNA content has been associated with aggressive clinical behavior and an unfavorable prognosis in several malignant human tumors. It was also described in differentiated thyroid carcinoma. Therefore, analysis of the nuclear DNA content may yield information predictive of aggressive behavior. Accordingly, the DNA content of the tall cell variant was measured and compared with that of the usual form of papillary carcinoma by flow cytometry. Although all the aneuploid tumors were in the tall cell variant group, the difference in nuclear content was not statistically significant. We conclude that differences in the clinical behavior of these neoplasms are not related to alterations in DNA ploidy.

Original languageEnglish
Pages (from-to)713-715
Number of pages3
JournalAnnals of Otology, Rhinology and Laryngology
Volume105
Issue number9
DOIs
StatePublished - 1996

Keywords

  • DNA content
  • flow cytometry
  • papillary thyroid carcinoma
  • tall cell carcinoma

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