@article{e77874e9705842c5b5f99ff56bde5208,
title = "NG-Nitro-L-arginine prevents morphine tolerance",
abstract = "NMDA receptor antagonists, such as MK-801, prevent the development of tolerance to morphine. Since many NMDA actions involve the production of nitric oxide, we examined the effects of a nitric oxide synthase inhibitor on morphine tolerance. The analgesic response to morphine (5 mg/kg s.c.) given daily diminishes from 60% in naive animals to 0% within 5 days. Coadministration of NG-nitro-L-arginine (8 mg/kg per day) along with morphine prevents the demonstration of appreciable tolerance for at least 11 days. These results suggest that morphine tolerance involves the activation of NMDA receptors followed by the subsequent release of nitric oxide.",
keywords = "NMDA receptor antagonists, NO synthase, Nitric oxide (NO)",
author = "Kolesnikov, {Yuri A.} and Pick, {Chaim G.} and Pasternak, {Gavril W.}",
note = "Funding Information: We thank DTR. Jerome Pusner and Richard Hawks for their assistance. This work was supported hy ;t Grmtt from the National Institute on Drug Abuse (D.417147) to G.W.P. Y.K. is supported. in part. by funds granted from the Norman and Rosita Winston Fnun-datirm and the Mich;u!l and Ethel Cohen Fellowship Fund. G.W.P. is :I rccinient of a Research Scientist Development Award from the Na:inna! Insrirore of Drug Abuse iDAb l3Xj.",
year = "1992",
month = oct,
day = "20",
doi = "10.1016/0014-2999(92)90732-J",
language = "אנגלית",
volume = "221",
pages = "399--400",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier B.V.",
number = "2-3",
}