N4-acetylation of Cytidine in mRNA by NAT10 Regulates Stability and Translation

Dan Dominissini*, Gideon Rechavi

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

56 Scopus citations

Abstract

Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N4-acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble positions of select codons, where it promotes stability and translation, possibly by safeguarding cognate codon-anticodon interaction. Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N4-acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble positions of select codons, where it promotes stability and translation, possibly by safeguarding cognate codon-anticodon interaction.

Original languageEnglish
Pages (from-to)1725-1727
Number of pages3
JournalCell
Volume175
Issue number7
DOIs
StatePublished - 13 Dec 2018

Funding

FundersFunder number
Horizon 2020 Framework Programme743168

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