TY - JOUR
T1 - N4-acetylation of Cytidine in mRNA by NAT10 Regulates Stability and Translation
AU - Dominissini, Dan
AU - Rechavi, Gideon
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/12/13
Y1 - 2018/12/13
N2 - Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N4-acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble positions of select codons, where it promotes stability and translation, possibly by safeguarding cognate codon-anticodon interaction. Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N4-acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble positions of select codons, where it promotes stability and translation, possibly by safeguarding cognate codon-anticodon interaction.
AB - Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N4-acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble positions of select codons, where it promotes stability and translation, possibly by safeguarding cognate codon-anticodon interaction. Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N4-acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble positions of select codons, where it promotes stability and translation, possibly by safeguarding cognate codon-anticodon interaction.
UR - http://www.scopus.com/inward/record.url?scp=85057845000&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2018.11.037
DO - 10.1016/j.cell.2018.11.037
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AN - SCOPUS:85057845000
SN - 0092-8674
VL - 175
SP - 1725
EP - 1727
JO - Cell
JF - Cell
IS - 7
ER -