Novel technique: A pupillometer-based objective chromatic perimetry

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Abstract

Evaluation of visual field (VF) is important for clinical diagnosis and patient monitoring. The current VF methods are subjective and require patient cooperation. Here we developed a novel objective perimetry technique based on the pupil response (PR) to multifocal chromatic stimuli in normal subjects and in patients with glaucoma and retinitis pigmentosa (RP). A computerized infrared video pupillometer was used to record PR to short- and long-wavelength stimuli (peak 485 nm and 620 nm, respectively) at light intensities of 15-100 cd-s/m2 at thirteen different points of the VF. The RP study included 30 eyes of 16 patients and 20 eyes of 12 healthy participants. The glaucoma study included 22 eyes of 11 patients and 38 eyes of 19 healthy participants. Significantly reduced PR was observed in RP patients in response to short-wavelength stimuli at 40 cd-s/m2 in nearly all perimetric locations (P <0.05). By contrast, RP patients demonstrated nearly normal PR to long-wavelength in majority of perimetric locations. The glaucoma group showed significantly reduced PR to long- and short-wavelength stimuli at high intensity in all perimetric locations (P <0.05). The PR of glaucoma patients was significantly lower than normal in response to short-wavelength stimuli at low intensity mostly in central and 20° locations (p<0.05). This study demonstrates the feasibility of using pupillometer-based chromatic perimetry for objectively assessing VF defects and retinal function and optic nerve damage in patients with retinal dystrophies and glaucoma. Furthermore, this method may be used to distinguish between the damaged cells underlying the VF defect.

Original languageEnglish
Title of host publicationOphthalmic Technologies XXIV
PublisherSPIE
ISBN (Print)9780819498434
DOIs
StatePublished - 2014
Externally publishedYes
Event24th Conference on Ophthalmic Technologies - San Francisco, CA, United States
Duration: 1 Feb 20142 Feb 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8930
ISSN (Print)1605-7422

Conference

Conference24th Conference on Ophthalmic Technologies
Country/TerritoryUnited States
CitySan Francisco, CA
Period1/02/142/02/14

Keywords

  • Glaucoma
  • Melanopsin-containing retinal ganglion cells
  • Perimetry
  • Pupil light reflex
  • Pupillometer
  • Retina
  • Retinitis pigmentosa
  • Visual fiel

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