Novel system for measuring giant spectral images and its application for cancer detection

Pramod Kumar, Irina Marin, Daniela Necula, Irena Bronshtein-Berger, Moshe Linder, Zav Shotan, Gali Zimmerman-Moreno, Arnaldo Mayer, Iris Barshack, Yuval Garini

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Spectral imaging is an important method that is used for a whole spectrum of applications, but measuring very large spectral images is a challenge that so far was not achieved. We present a novel system for scanning very large spectral images of microscopy samples in a rather short time. The system captures the information while the sample is continuously being scanned on the fly. It therefore breaks the size and speed limits that resulted from existing spectral imaging methods. The spectral separation is achieved through Fourier spectroscopy by using an interferometer mounted along the optical axis (no moving parts). We describe the system and its use for pathological samples.

Original languageEnglish
Title of host publicationImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV
EditorsDaniel L. Farkas, Dan V. Nicolau, Robert C. Leif
PublisherSPIE
ISBN (Electronic)9781510605770
DOIs
StatePublished - 2017
EventImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV - San Francisco, United States
Duration: 30 Jan 20171 Feb 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10068
ISSN (Print)1605-7422

Conference

ConferenceImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV
Country/TerritoryUnited States
CitySan Francisco
Period30/01/171/02/17

Funding

FundersFunder number
Israel Science Foundation51/12
Israeli Centers for Research Excellence1902/12

    Keywords

    • Digital pathology
    • H&E stained slides
    • Imaging
    • Sagnac Interferometer
    • Spectral Imaging
    • Spectroscopy

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