Novel method for incorporating the CHF2 group into organic molecules using BrF3

Revital Sasson, Aviv Hagooly, Shlomo Rozen

Research output: Contribution to journalArticlepeer-review

Abstract

(Matrix presented) 2-Alkyl-1,3-dithiane derivatives, easily made from alkyl bromides and the parent 1,3-dithiane, were reacted with BrF3 to form the corresponding 1,1-difluoromethyl alkanes (RCHF2) in 60-75% yield. The reaction proceeds well with primary alkyl halides. The limiting step for secondary alkyl halides is the relatively low yield of the dithiane preparation. The two sulfur atoms of the dithiane are essential for the reaction.

Original languageEnglish
Pages (from-to)769-771
Number of pages3
JournalOrganic Letters
Volume5
Issue number5
DOIs
StatePublished - 6 Mar 2003

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