Novel method for incorporating the CHF₂ group into organic molecules using BrF₃

(Matrix presented) 2-Alkyl-1,3-dithiane derivatives, easily made from alkyl bromides and the parent 1,3-dithiane, were reacted with BrF₃ to form the corresponding 1,1-difluoromethyl alkanes (RCHF₂) in 60-75% yield. The reaction proceeds well with primary alkyl halides. The limiting step for secondary alkyl halides is the relatively low yield of the dithiane preparation. The two sulfur atoms of the dithiane are essential for the reaction.