Novel Embolic Protection Device: a Feasibility Study

Elon Reshef, Doron Bushi, Udi Nussinovitch

Research output: Contribution to journalArticlepeer-review

Abstract

Stroke is ranked as the second leading cause of death worldwide. Ischemic stroke commonly results from emboli that originate in the heart among high-risk patients, such as those who develop atrial fibrillation. Yet, treatment is currently limited to anticoagulants, which may be associated with life-threatening bleeding. Our aim was to develop an alternative, device-based approach for continuous stroke prevention in high-risk patients. To this end, a novel endovascular tubular mesh was designed to be implanted in the aortic arch and to reroute emboli away from critical cerebral arteries. The feasibility of this approach as a means of ischemic stroke prevention was tested in vitro. The simulated cerebral perfusion pressures were not affected by the device. Also, the device efficiently diverted clinically meaningful embolic particles away from the cerebral circulation. It is proposed that this device could be used to reroute cardio-emboli away from intracranial vessels as a means of stroke prevention among patients for which anticoagulants are contraindicated.

Original languageEnglish
Pages (from-to)253-262
Number of pages10
JournalJournal of Cardiovascular Translational Research
Volume13
Issue number2
DOIs
StatePublished - 1 Apr 2020

Keywords

  • Anticoagulants
  • Embolic protection
  • Left atrial appendage occlusion
  • Stroke

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