TY - JOUR
T1 - Novel biodegradable composite wound dressings with controlled release of antibiotics
T2 - Results in a guinea pig burn model
AU - Elsner, Jonathan J.
AU - Egozi, Dana
AU - Ullmann, Yehuda
AU - Berdicevsky, Israela
AU - Shefy-Peleg, Adaya
AU - Zilberman, Meital
N1 - Funding Information:
The wound dressing materials remained in position over the course of treatment and were not disrupted. The dressing material created good contact with the skin, turning transparent in the exudating regions of the wound. All dressing materials used in the study were easily removed from the wound. Notable degradation of the binding matrix occurred in the regions subject to exudation, creating visible voids between the supporting fibers. This finding was supported by SEM photographs of different regions of the retrieved dressing material. The dressing's margin demonstrated negligible degradation while its center demonstrated advanced degradation. The fibrous mesh remained intact despite degradation of the binding matrix.
PY - 2011/8
Y1 - 2011/8
N2 - Approximately 70% of all people with severe burns die from related infections despite advances in treatment regimens and the best efforts of nurses and doctors. Silver ion-eluting wound dressings are available for overcoming this problem. However, there are reports of deleterious effects of such dressings due to cellular toxicity that delays the healing process, and the dressing changes needed 1-2 times a day are uncomfortable for the patient and time consuming for the stuff. An alternative concept in wound dressing design that combines the advantages of occlusive dressings with biodegradability and intrinsic topical antibiotic treatment is described herewith. The new composite structure presented in this article is based on a polyglyconate mesh and a porous poly-(dl-lactic-co-glycolic acid) matrix loaded with gentamicin developed to provide controlled release of antibiotics for three weeks. In vivo evaluation of the dressing material in contaminated deep second degree burn wounds in guinea pigs (n = 20) demonstrated its ability to accelerate epithelialization by 40% compared to an unloaded format of the material and a conventional dressing material. Wound contraction was reduced significantly, and a better quality scar tissue was formed. The current dressing material exhibits promising results, does not require frequent bandage changes, and offers a potentially valuable and economic approach to treating the life-threatening complication of burn-related infections.
AB - Approximately 70% of all people with severe burns die from related infections despite advances in treatment regimens and the best efforts of nurses and doctors. Silver ion-eluting wound dressings are available for overcoming this problem. However, there are reports of deleterious effects of such dressings due to cellular toxicity that delays the healing process, and the dressing changes needed 1-2 times a day are uncomfortable for the patient and time consuming for the stuff. An alternative concept in wound dressing design that combines the advantages of occlusive dressings with biodegradability and intrinsic topical antibiotic treatment is described herewith. The new composite structure presented in this article is based on a polyglyconate mesh and a porous poly-(dl-lactic-co-glycolic acid) matrix loaded with gentamicin developed to provide controlled release of antibiotics for three weeks. In vivo evaluation of the dressing material in contaminated deep second degree burn wounds in guinea pigs (n = 20) demonstrated its ability to accelerate epithelialization by 40% compared to an unloaded format of the material and a conventional dressing material. Wound contraction was reduced significantly, and a better quality scar tissue was formed. The current dressing material exhibits promising results, does not require frequent bandage changes, and offers a potentially valuable and economic approach to treating the life-threatening complication of burn-related infections.
KW - Gentamicin
KW - Histology
KW - Infection
KW - Poly-(dl-lactic-co-glycolic acid)
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=79960427562&partnerID=8YFLogxK
U2 - 10.1016/j.burns.2011.02.010
DO - 10.1016/j.burns.2011.02.010
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AN - SCOPUS:79960427562
SN - 0305-4179
VL - 37
SP - 896
EP - 904
JO - Burns
JF - Burns
IS - 5
ER -