Novel biodegradable composite wound dressings with controlled release of antibiotics: Results in a guinea pig burn model

Jonathan J. Elsner, Dana Egozi, Yehuda Ullmann, Israela Berdicevsky, Adaya Shefy-Peleg, Meital Zilberman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Approximately 70% of all people with severe burns die from related infections despite advances in treatment regimens and the best efforts of nurses and doctors. Silver ion-eluting wound dressings are available for overcoming this problem. However, there are reports of deleterious effects of such dressings due to cellular toxicity that delays the healing process, and the dressing changes needed 1-2 times a day are uncomfortable for the patient and time consuming for the stuff. An alternative concept in wound dressing design that combines the advantages of occlusive dressings with biodegradability and intrinsic topical antibiotic treatment is described herewith. The new composite structure presented in this article is based on a polyglyconate mesh and a porous poly-(dl-lactic-co-glycolic acid) matrix loaded with gentamicin developed to provide controlled release of antibiotics for three weeks. In vivo evaluation of the dressing material in contaminated deep second degree burn wounds in guinea pigs (n = 20) demonstrated its ability to accelerate epithelialization by 40% compared to an unloaded format of the material and a conventional dressing material. Wound contraction was reduced significantly, and a better quality scar tissue was formed. The current dressing material exhibits promising results, does not require frequent bandage changes, and offers a potentially valuable and economic approach to treating the life-threatening complication of burn-related infections.

Original languageEnglish
Pages (from-to)896-904
Number of pages9
JournalBurns
Volume37
Issue number5
DOIs
StatePublished - Aug 2011

Funding

FundersFunder number
Israel Ministry of Health3-3943
Israel Science Foundation1312/07

    Keywords

    • Gentamicin
    • Histology
    • Infection
    • Poly-(dl-lactic-co-glycolic acid)
    • Wound healing

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