@article{38555e453eb647fda1375a8d044e1af7,
title = "Novel associations for coronary artery disease derived from genome wide association studies are not associated with increased carotid intima-media thickness, suggesting they do not act via early atherosclerosis or vessel remodeling",
abstract = "Background: Recent genome-wide association studies (GWAS) have identified associations with myocardial infarction and coronary artery disease (CAD), but the mechanisms underlying these associations remain largely unclear. Carotid intima-media thickness (IMT) is a measure of early arterial remodeling and arteriosclerosis. Therefore, if CAD associated SNPs are also associated with carotid IMT; it suggests that they are acting via the early stages of the atherosclerotic process. Methods: In three large community based independent populations (CAPS, KORA and Young Finns) of European ancestry in which common carotid IMT had been measured (total 4961 individuals), we determined whether SNPs that have been associated with CAD in GWAS studies are also associated with carotid IMT. Associations with plaque were not examined. Results: We identified 11 SNPs and one haplotype previously associated with CAD. None of these were associated with common carotid IMT. Conclusions: We found no evidence that SNPs associated with CAD on GWAS are also associated with carotid IMT. This suggests these genetic associations are not acting via early vessel remodeling or early arteriosclerosis.",
keywords = "Atherosclerosis, Coronary artery disease, Genetics, Genome wide association, Intima-media thickness, Myocardial infarction",
author = "Lucia Conde and Steve Bevan and Matthias Sitzer and Norman Klopp and Thomas Illig and Joachim Thiery and Joachim Seissler and Jens Baumert and Olli Raitakari and Mika K{\"a}h{\"o}nen and Lyytik{\"a}inen, {Leo Pekka} and Reijo Laaksonen and Jorma Viikari and Terho Lehtim{\"a}ki and Wolfgang Koernig and Eran Halperin and Markus, {Hugh S.}",
note = "Funding Information: The study has been funded by a European Union 7th Framework Programme grant number 201668 for the AtheroRemo Project. In addition the individual studies received support from the following sources: CAPS: This study was supported by grants from the Stiftung Deutsche Schlaganfall-Hilfe (German Stroke Foundation). Young Finns Study: Academy of Finland (grants no. 117797 , 126925 , 121584 , 117941 ), the Social Insurance Institution of Finland , the Turku University Foundation , the Finnish Cultural Foundation , the Yrj{\"o} Jahnsson Foundation , the Emil Aaltonen Foundation (T.L.), Medical Research Fund of Tampere University Hospital (grant no. 9M048 ), Turku University Central Hospital Medical Fund , the Juho Vainio Foundation , and the Finnish Foundation for Cardiovascular Research and Tampere Tuberculosis Foundation (T.L, M.K). The MONICA/KORA Augsburg studies were financed by the Helmholtz Zentrum M{\"u}nchen , German Research Center for Environmental Health , Neuherberg, Germany and supported by grants from the German Federal Ministry of Education and Research (BMBF). Part of this work was financed by the German National Genome Research Network (NGFNPlus, project number 01GS0834) and through additional funds from the University of Ulm . Furthermore, the research was supported within the Munich Center of Health Sciences (MC Health) as part of LMU innovative. ",
year = "2011",
month = dec,
doi = "10.1016/j.atherosclerosis.2011.08.031",
language = "אנגלית",
volume = "219",
pages = "684--689",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",
}
