@article{d74fbb737b5645b2916eddd7747be224,
title = "Novel aspects of Sj{\"o}gren's syndrome in 2012",
abstract = "Sj{\"o}gren's syndrome (SS) is a systemic progressive autoimmune disease characterized by a complex pathogenesis requiring a predisposing genetic background and involving immune cell activation and autoantibody production. The immune response is directed to the exocrine glands, causing the typical 'sicca syndrome', but major organ involvement is also often seen. The etiology of the disease is unknown. Infections could play a pivotal role: compared to normal subjects, patients with SS displayed higher titers of anti-Epstein-Barr virus (EBV) early antigens, but lower titers of other infectious agent antibodies such as rubella and cytomegalovirus (CMV) suggest that some infections may have a protective role against the development of autoimmune disease. Recent findings seem to show that low vitamin D levels in patients with SS could be associated with severe complications such as lymphoma and peripheral neuropathy. This could open new insights into the disease etiology. The current treatments for SS range from symptomatic therapies to systemic immunosuppressive drugs, especially B cell-targeted drugs in cases of organ involvement. Vitamin D supplementation may be an additional tool for optimization of SS treatment.",
keywords = "Anti-B cell therapies, Autoantibodies, Autoimmune diseases, Chronic sialoadenitis, Dry eye syndrome, Lymphoma, Peripheral neuropathy, Sicca syndrome, Sj{\"o}gren's syndrome, Vitamin D",
author = "Angela Tincani and Laura Andreoli and Ilaria Cavazzana and Andrea Doria and Marta Favero and Fenini, {Maria Giulia} and Franco Franceschini and Andrea Lojacono and Giuseppe Nascimbeni and Amerigo Santoro and Francesco Semeraro and Paola Toniati and Yehuda Shoenfeld",
note = "Funding Information: We thank Dr Mirko Scarsi (Rheumatology and Clinical Immunology Unit, Brescia, Italy) for the concept and production of the figure on the cover page, and to Dr Barbara Arcidiacono (Ophthalmology Unit, Brescia) for support in the preparation of the {\textquoteleft}dry eye{\textquoteright} section. LA is supported by a Research Grant financed by an agreement between the Government of Lombardy and the University of Brescia ({\textquoteleft}Dote Ricercatore e Dote Ricerca Applicata ai sensi dell{\textquoteright}accordo regionale per lo sviluppo del capitale umano nel sistema universitario Lombardo sottoscritto tra Regione Lombardia e Universit{\`a} Lombarde il 20-10-2009, Universit{\`a} degli Studi di Brescia{\textquoteright}).",
year = "2013",
month = apr,
day = "4",
doi = "10.1186/1741-7015-11-93",
language = "אנגלית",
volume = "11",
journal = "BMC Medicine",
issn = "1741-7015",
publisher = "BioMed Central Ltd.",
number = "1",
}
