Novel approaches to treatment of autoimmune neuroinflammation and lessons for drug development

Eran Nizri; Michal Irony-Tur-Sinai; Nikolaos Grigoriadis; Oded Abramsky; Gabi Amitai; Talma Brenner

doi:10.1159/000097628

Novel approaches to treatment of autoimmune neuroinflammation and lessons for drug development

Eran Nizri
, Michal Irony-Tur-Sinai
, Nikolaos Grigoriadis
, Oded Abramsky
, Gabi Amitai
, Talma Brenner^*

^*Corresponding author for this work

Hadassah University Medical Centre
Aristotle University of Thessaloniki
IIBR

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Drug development, and especially that intended for central nervous system (CNS) disorders, still poses a challenge. We investigated both the use of bifunctional compounds designed for multiple targeting and enhanced CNS permeability, and of recombinant α-fetoprotein (AFP), a natural pregnancy-associated immunomodulating protein for the treatment of CNS inflammation. Bifunctional compounds showed a novel pharmacokinetic profile due to the conjugation, yet retained, and even improved pharmacodynamics. AFP was well tolerated and decreased various aspects of neuroinflammation, including disease severity, axonal loss and damage, T-cell reactivity, and antigen presentation. Our results show that both strategies may serve as future drug modalities.

Original language	English
Pages (from-to)	42-49
Number of pages	8
Journal	Pharmacology
Volume	79
Issue number	1
DOIs	https://doi.org/10.1159/000097628
State	Published - Jan 2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bifunctional molecules
Central nervous system inflammation
Drug development
Experimental autoimmune encephalomyelitis
Multiple sclerosis
Natural immunomodulating protein
α-Fetoprotein

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10.1159/000097628

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abstract = "Drug development, and especially that intended for central nervous system (CNS) disorders, still poses a challenge. We investigated both the use of bifunctional compounds designed for multiple targeting and enhanced CNS permeability, and of recombinant α-fetoprotein (AFP), a natural pregnancy-associated immunomodulating protein for the treatment of CNS inflammation. Bifunctional compounds showed a novel pharmacokinetic profile due to the conjugation, yet retained, and even improved pharmacodynamics. AFP was well tolerated and decreased various aspects of neuroinflammation, including disease severity, axonal loss and damage, T-cell reactivity, and antigen presentation. Our results show that both strategies may serve as future drug modalities.",

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AU - Irony-Tur-Sinai, Michal

AU - Grigoriadis, Nikolaos

AU - Abramsky, Oded

AU - Amitai, Gabi

AU - Brenner, Talma

PY - 2007/1

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AB - Drug development, and especially that intended for central nervous system (CNS) disorders, still poses a challenge. We investigated both the use of bifunctional compounds designed for multiple targeting and enhanced CNS permeability, and of recombinant α-fetoprotein (AFP), a natural pregnancy-associated immunomodulating protein for the treatment of CNS inflammation. Bifunctional compounds showed a novel pharmacokinetic profile due to the conjugation, yet retained, and even improved pharmacodynamics. AFP was well tolerated and decreased various aspects of neuroinflammation, including disease severity, axonal loss and damage, T-cell reactivity, and antigen presentation. Our results show that both strategies may serve as future drug modalities.

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KW - Central nervous system inflammation

KW - Drug development

KW - Experimental autoimmune encephalomyelitis

KW - Multiple sclerosis

KW - Natural immunomodulating protein

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Novel approaches to treatment of autoimmune neuroinflammation and lessons for drug development

Abstract

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Keywords

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