Novel antibiotic-eluting wound dressings: An in vitro study and engineering aspects in the dressing's design

Jonathan J. Elsner, Meital Zilberman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Wound dressings aim to restore the milieu required for skin regeneration by protecting the wound from environmental threats, including penetration of bacteria, and by maintaining a moist healing environment. A wide variety of wound dressing products targeting various types of wounds and different aspects of the wound healing process are currently available on the market. Ideally, a dressing should be easy to apply and remove, and its design should meet both physical and mechanical requirements; namely water absorbance and transmission rate, handleability and strength. In this article, our novel biodegradable antibiotic-eluting wound dressings are described and the engineering aspects in the design are emphasized. These unique new wound dressings are based on a polyglyconate mesh, coated with a porous Poly(dl-lactic-co-glycolic acid) matrix. They demonstrated excellent mechanical and physical properties and desired release profiles of antibiotic drugs which enable bacterial inhibition. Hence, a new generation of wound dressings is now emerging with clear benefits. These include better protection against infection and reducing the need for frequent dressing changing.

Original languageEnglish
Pages (from-to)54-66
Number of pages13
JournalJournal of Tissue Viability
Volume19
Issue number2
DOIs
StatePublished - May 2010

Funding

FundersFunder number
Israel Science Foundation1312/07
Ministry of Health, State of Israel3-3943

    Keywords

    • Ceftazidime
    • Controlled drug delivery
    • Water absorption
    • Water vapor transmission rate
    • poly-(DL-lactic-co-glycolic acid)

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