@article{064f7418a071475faaef2324faa63f70,
title = "NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression",
abstract = "Anterior segment dysgenesis is often associated with cornea diseases, cataracts, and glaucoma. In the anterior segment, the ciliary body (CB) containing inner and outer ciliary epithelia (ICE and OCE) secretes aqueous humor that maintains intraocular pressure (IOP). However, CB development and function remain poorly understood. Here, this study shows that NOTCH signaling in the CB maintains the vitreous, IOP, and eye structures by regulating CB morphogenesis, aqueous humor secretion, and vitreous protein expression. Notch2 and Notch3 function via RBPJ in the CB to control ICE-OCE adhesion, CB morphogenesis, aqueous humor secretion, and protein expression, thus maintaining IOP and eye structures. Mechanistically, NOTCH signaling transcriptionally controls Nectin1 expression in the OCE to promote cell adhesion for driving CB morphogenesis and to directly stabilize Cx43 for controlling aqueous humor secretion. Finally, NOTCH signaling directly controls vitreous protein secretion in the ICE. Therefore, this study provides important insight into CB functions and involvement in eye diseases.",
keywords = "Cx43, IOP, NOTCH signaling, Nectin1, anterior segment, aqueous humor, ciliary body, eye degeneration, morphogenesis, secretion, viteous",
author = "Ji Pang and Liang Le and Yi Zhou and Renjun Tu and Qiang Hou and Dai Tsuchiya and Nancy Thomas and Yongfu Wang and Zulin Yu and Richard Alexander and Marina Thexton and Brandy Lewis and Timothy Corbin and Michael Durnin and Hua Li and Ruth Ashery-Padan and Deyue Yan and Ting Xie",
note = "Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2021",
month = jan,
day = "12",
doi = "10.1016/j.celrep.2020.108603",
language = "אנגלית",
volume = "34",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "2",
}
