Nosocomial coagulase-negative staphylococcal infections in bone marrow transplantation recipients with central vein catheter: A 5-year prospective study

Dan Engelhard*, Hanita Elishoov, Nurith Strauss, Elizabeth Naparstek, Arnon Nagler, Alberto Simhon, David Raveh, Shimon Slavin, Reuven Or

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The purpose of this study was to examine coagulase-negative staphylococcal infections in bone marrow transplantation (BMT) patients with central vein catheters by investigating incidence, clinical relevance, risk factors, methicillin resistance, clinical impact of initial empiric antimicrobial therapy without vancomycin, and management of documented catheter-related infections. A 5-year prospective study was conducted with daily evaluation of 242 BMT patients during hospitalization, including clinical assessment and blood culture via the Hickman/Broviac catheter. If fever or infected appearance occurred, peripheral blood cultures or exit site cultures, respectively, were done. Results showed a septicemia incidence of 7.0%, including in 6 patients following colonization, in 1 patient with tunnel infection, in 1 patient with thrombophlebitis, in 1 patient with exit site infection, and in 8 patients with septicemia of unknown origin. Total colonization incidence was 7%, with colonization only in 11 patients who had 16 episodes; incidence of exit site infection was 3.7%. Age ≥18 years was the only identified risk factor for developing staphylococcal infection (P=0.03). Despite a methicillin resistance rate of 45% and omission of vancomycin from the routine initial empiric antimicrobial regimen, the clinical course of coagulase-negative staphylococcal infections was relatively benign. A single patient, who experienced marrow rejection, died on day +31 with septicemia and only one patient experienced microbiological failure wit h recurrent colonization. Bacteria grown in both aerobic and anaerobic bottles were more likely true bacteremia than contaminant (P=0.03). We conclude that the hazard of coagulase-negative staphylococcal infection does not mandate inclusion of a glycopeptide in the initial empiric antimicrobial regimen in BMT patients, even during febrile neutropenia. Hickman/Broviac-related staphylococcal infections, except for tunnel infection or thrombophlebitis, can usually be treated successfully without removing the catheter.

Original languageEnglish
Pages (from-to)430-434
Number of pages5
Issue number3
StatePublished - 15 Feb 1996
Externally publishedYes


Dive into the research topics of 'Nosocomial coagulase-negative staphylococcal infections in bone marrow transplantation recipients with central vein catheter: A 5-year prospective study'. Together they form a unique fingerprint.

Cite this