Nosocomial bloodstream infections in a pediatric intensive care unit: 3-Year survey

Galia Grisaru-Soen*, Yaser Sweed, Liat Lerner-Geva, Galit Hirsh-Yechezkel, Valentina Boyko, Amir Vardi, Nathan Keller, Zohar Barzilay, Gideon Paret

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Bloodstream infections (BSI) represent a major cause of hospital-acquired infections in pediatric intensive care unit (PICU) patients. This study was designed to determine the prevalence, risk factors and outcomes of these infections in one local facility. Material/Methods: All patients admitted to one PICU between January 1, 2000-December 31, 2002 and subsequently developed a nosocomial bloodstream infection (NBSI) were consecutively recruited. The study was a retrospective study. Data retrieved from medical records included demographic information, extrinsic (invasive devices) and intrinsic risk factors, specific pathogens, therapeutic interventions and outcome. Results: There were 95 episodes of NBSIs in 59 patients (63/1711 PICU admissions, yielding an incidence of 56/1000). The crude mortality rate (CMR) in children with NBSIs was 52%, compared with 6% for all other children admitted to the PICU. A higher CMR was associated with hemato-oncology illness, prolonged length of hospitalization (>1 month) mechanical ventilation, dialysis and severity of illness. Most of the patients (95%) had central intravascular devices, and 73% of the episodes were catheter-related infections. The most frequent pathogens were coagulase-negative staphylococci (24%), Klebsiella pneumonia (16%), Candida spp. (15%), Pseudomonas aeruginosa (7%) and Staphylococcus aureus (6%). Thirty-three percent of the Staphylococcus aureus were methicillin resistant (MRSA) and 30% of the Klebsiella pneumonia were extended - spectrum beta-lactamase - producing (ESBL) strains. Conclusions: The overall incidence of NBSIs was 56 episodes per 1000 admissions. The major risk factors were hemato-oncology illness, prolonged length of hospitalization, mechanical ventilation, dialysis and severity of illness. Children with NBSI had a poor outcome when compared with children without NBSI.

Original languageEnglish
Pages (from-to)CR251-CR257
JournalMedical Science Monitor
Issue number6
StatePublished - Jun 2007
Externally publishedYes


  • Blood stream infection
  • Nosocomial
  • Pediatric intensive care unit


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