Norovirus: Facts and reflections from past, present, and future

Yalda Lucero, David O. Matson, Shai Ashkenazi, Sergio George, Miguel O’ryan

Research output: Contribution to journalReview articlepeer-review


Human Norovirus is currently the main viral cause of acute gastroenteritis (AGEs) in most countries worldwide. Nearly 50 years after the discovery of the “Norwalk virus” by Kapikian and colleagues, the scientific and medical community continue to generate new knowledge on the full biological and disease spectrum of Norovirus infection. Nevertheless, several areas remain incompletely understood due to the serious constraints to effectively replicate and propagate the virus. Here, we present a narrated historic perspective and summarize our current knowledge, including insights and reflections on current points of interest for a broad medical community, including clinical and molecular epidemiology, viral–host–microbiota interactions, antivirals, and vaccine prototypes. We also include a reflection on the present and future impacts of the COVID-19 pandemic on Norovirus infection and disease.

Original languageEnglish
Article number2399
Issue number12
StatePublished - Dec 2021
Externally publishedYes


  • Epidemiology
  • Norovirus
  • Prevention
  • Vaccine


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