TY - JOUR
T1 - Normal response of factor VIII and von willebrand factor to 1-Deamino-8D-Arginine vasopressin in nephrogenic diabetes insipidus
AU - Brenner, B.
AU - Seligsohn, U.
AU - Hochberg, Z.
PY - 1988/7
Y1 - 1988/7
N2 - The effects of 1-deamino-8D-arginine vasopressin (DDAVP) on plasma factor VIII and von Willebrand factor (vWF) levels were studied in four patients with nephrogenic diabetes insipidus (NDI) from two unrelated families. While the urine osmolality remained low, the plasma levels of factor VIII and vWF rose 2- to 3-fold after infusion of 0.3 μg/kg DDAVP, compared to preinfusion levels. The degree of increase was similar in both NDI patients and normal subjects. We conclude that in NDI patients the end-organ resistance to DDAVP is confined to the kidneys and does not involve the sites from which factor VIII and vWF are released.
AB - The effects of 1-deamino-8D-arginine vasopressin (DDAVP) on plasma factor VIII and von Willebrand factor (vWF) levels were studied in four patients with nephrogenic diabetes insipidus (NDI) from two unrelated families. While the urine osmolality remained low, the plasma levels of factor VIII and vWF rose 2- to 3-fold after infusion of 0.3 μg/kg DDAVP, compared to preinfusion levels. The degree of increase was similar in both NDI patients and normal subjects. We conclude that in NDI patients the end-organ resistance to DDAVP is confined to the kidneys and does not involve the sites from which factor VIII and vWF are released.
UR - http://www.scopus.com/inward/record.url?scp=0023694013&partnerID=8YFLogxK
U2 - 10.1210/jcem-67-1-191
DO - 10.1210/jcem-67-1-191
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AN - SCOPUS:0023694013
VL - 67
SP - 191
EP - 193
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 1
ER -
