Normal response of factor VIII and von willebrand factor to 1-Deamino-8D-Arginine vasopressin in nephrogenic diabetes insipidus

B. Brenner, U. Seligsohn, Z. Hochberg

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of 1-deamino-8D-arginine vasopressin (DDAVP) on plasma factor VIII and von Willebrand factor (vWF) levels were studied in four patients with nephrogenic diabetes insipidus (NDI) from two unrelated families. While the urine osmolality remained low, the plasma levels of factor VIII and vWF rose 2- to 3-fold after infusion of 0.3 μg/kg DDAVP, compared to preinfusion levels. The degree of increase was similar in both NDI patients and normal subjects. We conclude that in NDI patients the end-organ resistance to DDAVP is confined to the kidneys and does not involve the sites from which factor VIII and vWF are released.

Original languageEnglish
Pages (from-to)191-193
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume67
Issue number1
DOIs
StatePublished - Jul 1988
Externally publishedYes

Fingerprint

Dive into the research topics of 'Normal response of factor VIII and von willebrand factor to 1-Deamino-8D-Arginine vasopressin in nephrogenic diabetes insipidus'. Together they form a unique fingerprint.

Cite this