TY - JOUR
T1 - Normal left ventricular performance documented by doppler echocardiography in patients with long-standing hypocalcemia
AU - Vered, Iris
AU - Vered, Zvi
AU - Perez, Julio E.
AU - Jaffe, Allan S.
AU - Whyte, Michael P.
N1 - Funding Information:
From the Metabolic Research Unit, Shriners Hospital for Crippled Children, and the Division of Endocrinology and Metabolism and the Division of Cardr-ology, Washington University School of Medicine, St. Louis, Missouri. This work was supported in part by Grant 15958 from the Shriners Hospitals for Crippled Children and by Grant HL-17646 from the National Institutes of Health Specialized Centers of Research in lschemic Heart Disease. This work was presented at the Lawrence and Dorothy Fallis International Symposium on Clinical Disorders of Bone and Mineral Metabolism, May 8-13. 1988, Detroit, Michigan. Requests for reprints should be addressed to Michael P. Whyte, M.D.. Metabolic Research Unit, Shriners Hospitals for Crippled Children. 2001 South Lindbergh Boulevard, St. Louis, Missouri 63131. Manuscript submitted August 3.1988. and accepted in revised form January 25, 1989.
PY - 1989
Y1 - 1989
N2 - introduction: Several reports suggest significantly reduced left ventricular performance in subjects with chronic hypocalcemia. We prospectively investigated eight patients, aged 13 to 31 years, with long-standing hypocalcemia due to idiopathic hypoparathyroidism or pseudohypoparathyroidism by echocardiography. patients and methods: Six subjects had symptomatic hypocalcemia manifested as recurrent tetany (four), seizures (four), mental retardation (three), behavior disorder (one), and skeletal abnormalities (four); three subjects were untreated when studied. None had carciovascular symptoms. Each patient underwent clinical, biochemical, and cardiac studies, including Doppler, two-dimensional, and M-mode echocardiography, on the same day. results: In serum, both total and ionized calcium concentrations were reduced and averaged 7.2 mg/dl (range: 5.3 to 8.5 mg/dl; normal: 9.0 to 10.3 mg/dl) and 3.6 mg/dl (range: 3.0 to 3.9 mg/dl; normal: 4.5 to 5.3 mg/dl), respectively. Electrocardiograms revealed prolonged QTc intervals in six patients. Also noted were prominent U waves (five), T-wave abnormalities (four), and right-axis deviation (one). Resting echocardiography, however, demonstrated normal left ventricular function in all subjects. All M-mode measurements were normal. Two-dimen-sional-derived left ventricular end-diastolic and end-systolic volumes were 87.1 ± 20.1 ml and 30.2 ± 9.7 ml (mean ± SD), respectively. Left ventricular ejection fraction was 65 percent (61.2 to 74.7 percent). Doppler-derived cardiac output and cardiac index averaged 5.1 liters/minutes (2.9 to 6.7 liters/minute) and 3.0 liters/minute/m2 (1.7 to 4.3 liters/minute/,2), respectively. conclusion: Our prospective study of eight subjects with functional hypoparathyroidism demonstrated that, despite electrocardiographic abnormalities, long-standing hypocalcemia was not associated with left ventricular dysfunction.
AB - introduction: Several reports suggest significantly reduced left ventricular performance in subjects with chronic hypocalcemia. We prospectively investigated eight patients, aged 13 to 31 years, with long-standing hypocalcemia due to idiopathic hypoparathyroidism or pseudohypoparathyroidism by echocardiography. patients and methods: Six subjects had symptomatic hypocalcemia manifested as recurrent tetany (four), seizures (four), mental retardation (three), behavior disorder (one), and skeletal abnormalities (four); three subjects were untreated when studied. None had carciovascular symptoms. Each patient underwent clinical, biochemical, and cardiac studies, including Doppler, two-dimensional, and M-mode echocardiography, on the same day. results: In serum, both total and ionized calcium concentrations were reduced and averaged 7.2 mg/dl (range: 5.3 to 8.5 mg/dl; normal: 9.0 to 10.3 mg/dl) and 3.6 mg/dl (range: 3.0 to 3.9 mg/dl; normal: 4.5 to 5.3 mg/dl), respectively. Electrocardiograms revealed prolonged QTc intervals in six patients. Also noted were prominent U waves (five), T-wave abnormalities (four), and right-axis deviation (one). Resting echocardiography, however, demonstrated normal left ventricular function in all subjects. All M-mode measurements were normal. Two-dimen-sional-derived left ventricular end-diastolic and end-systolic volumes were 87.1 ± 20.1 ml and 30.2 ± 9.7 ml (mean ± SD), respectively. Left ventricular ejection fraction was 65 percent (61.2 to 74.7 percent). Doppler-derived cardiac output and cardiac index averaged 5.1 liters/minutes (2.9 to 6.7 liters/minute) and 3.0 liters/minute/m2 (1.7 to 4.3 liters/minute/,2), respectively. conclusion: Our prospective study of eight subjects with functional hypoparathyroidism demonstrated that, despite electrocardiographic abnormalities, long-standing hypocalcemia was not associated with left ventricular dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=0024599597&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(89)90338-0
DO - 10.1016/0002-9343(89)90338-0
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AN - SCOPUS:0024599597
SN - 0002-9343
VL - 86
SP - 413
EP - 416
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 4 C
ER -