Normal hematopoietic reconstitution following ASTA-Z 7557-purged grafts in the absence of in vitro CFU-GM colony growth

A. Nagler; M. Mumcuoglu; E. Naparstek; R. Or; S. Gan; S. Slavin

doi:10.1016/0145-2126(93)90142-8

Normal hematopoietic reconstitution following ASTA-Z 7557-purged grafts in the absence of in vitro CFU-GM colony growth

A. Nagler^*, M. Mumcuoglu, E. Naparstek, R. Or, S. Gan, S. Slavin

^*Corresponding author for this work

Hadassah University Medical Centre

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Hematopoietic reconstitution was assessed in 26 consecutive patients who underwent autologous bone marrow transplantation (ABMT) with ASTA-Z 7557 purged bone marrows. Of the 26, 17 had acute non-lymphoblastic leukemia (ANLL), 7 had acute lymphoblastic leukemia (ALL), 1 had non-Hodgkin's lymphoma (NHL) and 1 had multiple myeloma (MM). Twelve patients had practically no CFU-GM growth after ASTA-Z treatment. No statistical difference was observed in hematopoietic reconstitution between patients with or without in vitro CFU-GM colony growth. No significant linear correlation was observed between CFU-GM content in the treated graft and day of engraftment. In vitro CFU-GM growth has no predictive value in assessing hematopoietic recovery in vivo. Patients with no CFU-GM growth demonstrated normal engraftment.

Original language	English
Pages (from-to)	61-67
Number of pages	7
Journal	Leukemia Research
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/0145-2126(93)90142-8
State	Published - Jan 1993
Externally published	Yes

Keywords

ASTA-Z 7557 purging
CFU-GM colony growth
autologous bone marrow transplantation
hematopoietic reconstitution

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0145-2126(93)90142-8

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title = "Normal hematopoietic reconstitution following ASTA-Z 7557-purged grafts in the absence of in vitro CFU-GM colony growth",

abstract = "Hematopoietic reconstitution was assessed in 26 consecutive patients who underwent autologous bone marrow transplantation (ABMT) with ASTA-Z 7557 purged bone marrows. Of the 26, 17 had acute non-lymphoblastic leukemia (ANLL), 7 had acute lymphoblastic leukemia (ALL), 1 had non-Hodgkin's lymphoma (NHL) and 1 had multiple myeloma (MM). Twelve patients had practically no CFU-GM growth after ASTA-Z treatment. No statistical difference was observed in hematopoietic reconstitution between patients with or without in vitro CFU-GM colony growth. No significant linear correlation was observed between CFU-GM content in the treated graft and day of engraftment. In vitro CFU-GM growth has no predictive value in assessing hematopoietic recovery in vivo. Patients with no CFU-GM growth demonstrated normal engraftment.",

keywords = "ASTA-Z 7557 purging, CFU-GM colony growth, autologous bone marrow transplantation, hematopoietic reconstitution",

author = "A. Nagler and M. Mumcuoglu and E. Naparstek and R. Or and S. Gan and S. Slavin",

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AU - Naparstek, E.

AU - Or, R.

AU - Gan, S.

AU - Slavin, S.

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AB - Hematopoietic reconstitution was assessed in 26 consecutive patients who underwent autologous bone marrow transplantation (ABMT) with ASTA-Z 7557 purged bone marrows. Of the 26, 17 had acute non-lymphoblastic leukemia (ANLL), 7 had acute lymphoblastic leukemia (ALL), 1 had non-Hodgkin's lymphoma (NHL) and 1 had multiple myeloma (MM). Twelve patients had practically no CFU-GM growth after ASTA-Z treatment. No statistical difference was observed in hematopoietic reconstitution between patients with or without in vitro CFU-GM colony growth. No significant linear correlation was observed between CFU-GM content in the treated graft and day of engraftment. In vitro CFU-GM growth has no predictive value in assessing hematopoietic recovery in vivo. Patients with no CFU-GM growth demonstrated normal engraftment.

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Normal hematopoietic reconstitution following ASTA-Z 7557-purged grafts in the absence of in vitro CFU-GM colony growth

Abstract

Keywords

UN SDGs

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