TY - JOUR
T1 - Normal diurnal variation in serum cortisol concentration in asthmatic children treated with inhaled budesonide
AU - Volovitz, Benjamin
AU - Kauschansky, Arieh
AU - Nussinovitch, Moshe
AU - Harel, Liora
AU - Varsano, Itzhak
PY - 1995/12
Y1 - 1995/12
N2 - Background: Twenty-four-hour serum cortisol secretion is a sensitive parameter for the assessment of the pituitary-adrenal function of asthmatic children treated with inhaled corticosteroids. This study was undertaken to determine the effect of the long-term administration of inhaled budesonide on 24-hour cortisol production in young children with asthma. Methods: We studied 11 children, aged 7 to 12 years, with severe perennial asthma. All had been receiving 100 μg of inhaled budesonide twice daily, administered with a spacer device, for 3 to 5 years. Serum cortisol concentration was measured at 8:00 AM, 60 minutes after intravenous administration of 0.25 mg of corticotropin, and every 30 minutes for 24 hours in an open-design study. Urinary cortisol secretion was measured by 24-hour urine collection. All determinations were made with a radioimmunoassay kit. Results: The individual morning serum cortisol concentration and the serum cortisol concentration at 60 minutes after corticotropin stimulation were within normal limits in all children. The 24-hour urinary cortisol excretion was also normal. The individual 24-hour serum cortisol concentration showed a normal pattern in all children, with no evidence of nocturnal suppression of serum cortisol concentration. Conclusion: Prolonged (3 to 5 years) administration of 200 μg/day of inhaled budesonide in young children with severe asthma does not impair pituitary-adrenal function, even according to the sensitive test for 24-hour serum cortisol secretion. (J ALLERGY CLIN IMMUNOL 1995;96:874-8.).
AB - Background: Twenty-four-hour serum cortisol secretion is a sensitive parameter for the assessment of the pituitary-adrenal function of asthmatic children treated with inhaled corticosteroids. This study was undertaken to determine the effect of the long-term administration of inhaled budesonide on 24-hour cortisol production in young children with asthma. Methods: We studied 11 children, aged 7 to 12 years, with severe perennial asthma. All had been receiving 100 μg of inhaled budesonide twice daily, administered with a spacer device, for 3 to 5 years. Serum cortisol concentration was measured at 8:00 AM, 60 minutes after intravenous administration of 0.25 mg of corticotropin, and every 30 minutes for 24 hours in an open-design study. Urinary cortisol secretion was measured by 24-hour urine collection. All determinations were made with a radioimmunoassay kit. Results: The individual morning serum cortisol concentration and the serum cortisol concentration at 60 minutes after corticotropin stimulation were within normal limits in all children. The 24-hour urinary cortisol excretion was also normal. The individual 24-hour serum cortisol concentration showed a normal pattern in all children, with no evidence of nocturnal suppression of serum cortisol concentration. Conclusion: Prolonged (3 to 5 years) administration of 200 μg/day of inhaled budesonide in young children with severe asthma does not impair pituitary-adrenal function, even according to the sensitive test for 24-hour serum cortisol secretion. (J ALLERGY CLIN IMMUNOL 1995;96:874-8.).
KW - Diurnal variation
KW - asthma inhaled corticosteroids
KW - budesonide
KW - children
KW - serum cortisol
UR - http://www.scopus.com/inward/record.url?scp=0029584467&partnerID=8YFLogxK
U2 - 10.1016/S0091-6749(95)70222-9
DO - 10.1016/S0091-6749(95)70222-9
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AN - SCOPUS:0029584467
SN - 0091-6749
VL - 96
SP - 874
EP - 878
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 6
ER -