Noonan's syndrome and hypopituitarism

J. L. Ross, L. Shenkman

Research output: Contribution to journalArticlepeer-review


A 37-year-old man with Noonan's hypopituitarism is described. The patient had small stature, minor facial abnormalities, cubitus valgus and pectus excavatum. In addition, endocrine testing revealed deficiencies of growth hormone, gonadotrophins and TSH. Prolactin increased normally in response to TRH administration, but failed to rise after chlorpromazine. Although intrinsic pituitary dysfunction cannot be excluded, the dissociated response of prolactin to TRH and chlorpromazine suggests that the pituitary hormone deficiencies may be secondary to hypothalamic dysfunction.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalAmerican Journal of the Medical Sciences
Issue number1
StatePublished - 1980
Externally publishedYes


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