TY - JOUR
T1 - Nontyphoid salmonella bacteremia
T2 - Age-related differences in clinical presentation, bacteriology, and outcome
AU - Shimoni, Z.
AU - Pitlik, S.
AU - Leibovici, L.
AU - Samra, Z.
AU - Konigsberger, H.
AU - Drucker, M.
AU - Agmon, V.
AU - Ashkenazi, S.
AU - Weinberger, M.
N1 - Funding Information:
Received 3 March 1998; revised 5 November 1998. Grant support: This work was supported in part by the Chief Scientist, Israel Ministry of Health (grant no. 4347). Reprints or correspondence: Dr. Miriam Weinberger, Department of Internal Medicine C and Infectious Diseases, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel.
PY - 1999
Y1 - 1999
N2 - In a retrospective study, 80 episodes of nontyphoid salmonella (NTS) bacteremia in children were compared with 55 episodes in adults over a 10- year period. The study disclosed major differences in the predisposition, clinical presentation, and outcome as well as the microbiology of NTS bacteremia in relation to age. Adults were more likely than children to have predisposing diseases (95% vs. 15%, respectively; P < .0001) and to receive prior medications (95% vs. 23%, respectively; P < .0001), particularly immunosuppressive agents (58% vs. 5%, respectively; P < .0001). In most adults (67%), NTS infection presented as a primary bacteremia and was associated with a high incidence of extraintestinal organ involvement (34%) and a high mortality rate (33%). In children, NTS bacteremia was usually secondary to gastroenteritis (75%) and caused no fatalities. Although group D Salmonella (78%) and the serovar Salmonella enteritidis were the predominant isolates from adults, the emergence of infections due to group C Salmonella (46%) and the serovar Salmonella virchow in children was noted.
AB - In a retrospective study, 80 episodes of nontyphoid salmonella (NTS) bacteremia in children were compared with 55 episodes in adults over a 10- year period. The study disclosed major differences in the predisposition, clinical presentation, and outcome as well as the microbiology of NTS bacteremia in relation to age. Adults were more likely than children to have predisposing diseases (95% vs. 15%, respectively; P < .0001) and to receive prior medications (95% vs. 23%, respectively; P < .0001), particularly immunosuppressive agents (58% vs. 5%, respectively; P < .0001). In most adults (67%), NTS infection presented as a primary bacteremia and was associated with a high incidence of extraintestinal organ involvement (34%) and a high mortality rate (33%). In children, NTS bacteremia was usually secondary to gastroenteritis (75%) and caused no fatalities. Although group D Salmonella (78%) and the serovar Salmonella enteritidis were the predominant isolates from adults, the emergence of infections due to group C Salmonella (46%) and the serovar Salmonella virchow in children was noted.
UR - http://www.scopus.com/inward/record.url?scp=0032958396&partnerID=8YFLogxK
U2 - 10.1086/515186
DO - 10.1086/515186
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AN - SCOPUS:0032958396
SN - 1058-4838
VL - 28
SP - 822
EP - 827
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 4
ER -