Nonpharmacological interventions for ‘no-option’ refractory angina patients

Yoav Paz*, Yair Levy, Liza Grosman-Rimon, Amihay Shinfeld

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Refractory angina pectoris (RAP) defined as chronic anginal chest pain because of coronary artery disease (CAD) is a major problem. The increase in the number of patients with RAP in recent years is because of the increasing aging population and improved survival rates among patients with CAD. Management of patients with RAP is often extremely challenging. In this review, we present several interventional approaches for RAP, including device therapies, lifestyle intervention, and cell therapies. Some of these treatments are currently used in the management of RAP, whereas other treatments are under investigation.

Original languageEnglish
Pages (from-to)13-22
Number of pages10
JournalJournal of Cardiovascular Medicine
Issue number1
StatePublished - 1 Jan 2024
Externally publishedYes


  • chronic anginal chest pain
  • coronary artery disease
  • refractory angina pectoris


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