Nonparticipation Selection Bias in the MOBI-Kids Study

Michelle C. Turner*, Esther Gracia-Lavedan, Franco Momoli, Chelsea E. Langer, Gemma Castaño-Vinyals, Michael Kundi, Milena Maule, Franco Merletti, Siegal Sadetzki, Roel Vermeulen, Alex Albert, Juan Alguacil, Nuria Aragones, Francesc Badia, Revital Bruchim, Gema Carretero, Noriko Kojimahara, Brigitte Lacour, Maria Morales-Suarez-Varela, Katja RadonThomas Remen, Tobias Weinmann, Naohito Yamaguchi, Elisabeth Cardis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: MOBI-Kids is a 14-country case-control study designed to investigate the potential effects of electromagnetic field exposure from mobile telecommunications devices on brain tumor risk in children and young adults conducted from 2010 to 2016. This work describes differences in cellular telephone use and personal characteristics among interviewed participants and refusers responding to a brief nonrespondent questionnaire. It also assesses the potential impact of nonparticipation selection bias on study findings. Methods: We compared nonrespondent questionnaires completed by 77 cases and 498 control refusers with responses from 683 interviewed cases and 1501 controls (suspected appendicitis patients) in six countries (France, Germany, Israel, Italy, Japan, and Spain). We derived selection bias factors and estimated inverse probability of selection weights for use in analysis of MOBI-Kids data. Results: The prevalence of ever-regular use was somewhat higher among interviewed participants than nonrespondent questionnaire respondents 10-14 years of age (68% vs. 62% controls, 63% vs. 48% cases); in those 20-24 years, the prevalence was ≥97%. Interviewed controls and cases in the 15- to 19- and 20- to 24-year-old age groups were more likely to have a time since start of use of 5+ years. Selection bias factors generally indicated a small underestimation in cellular telephone odds ratios (ORs) ranging from 0.96 to 0.97 for ever-regular use and 0.92 to 0.94 for time since start of use (5+ years), but varied in alternative hypothetical scenarios considered. Conclusions: Although limited by small numbers of nonrespondent questionnaire respondents, findings generally indicated a small underestimation in cellular telephone ORs due to selective nonparticipation.

Original languageEnglish
Pages (from-to)145-153
Number of pages9
Issue number1
StatePublished - 1 Jan 2019


FundersFunder number
Andalusian Con-sejeria de SaludPI-0317/2010
Chaim Sheba Medical Center
Epidemiology and Biostatistics Sorbonne Paris Cité Centre
French National Agency for Sanitary Safety of Food, Environment and Labour
Hospital del Mar Medical Research Institute
Public Health Division
University Hospital
cCIBER Epidemiología y Salud Pública
fChildren’s Hospital of Eastern Ontario Research Institute
Pfizer Foundation
Seventh Framework Programme226873, 603794
Department of Health and Social Care
European Commission
Universiteit Utrecht
Ministerio de Educación, Cultura y DeporteFISPI10/02981
Generalitat Valenciana025/2010
Tel Aviv University
Ministerio de Ciencia e Innovación
Universidad de Huelva
Ludwig-Maximilians-Universität München
Medizinische Universität Wien
Institut National du Cancer
Bundesamt für Strahlenschutz
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du TravailFSRF2008-3
Ministry of Internal Affairs and Communications0155-0007
Tokyo Women's Medical University
Departament de Salut, Generalitat de CatalunyaSLT002/16/00232
Conselleria de Sanitat Universal i Salut Pública
Centre hospitalier régional universitaire de LillerInserm U1153
mDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences
nResearch Center on Natural Resources, Health and Environment
pDepartment of Public Health
qFrench National Registry of Childhood Solid Tumors


    • Adolescents
    • Brain tumors
    • Case-control study
    • Cellular telephone use
    • Children
    • Epidemiologic methods
    • Selection bias


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