Noninvasive monitoring of peripheral microcirculatory hemodynamics under varying degrees of hypoxia

Zehava Ovadia-Blechman*, Aviram Meilin, Neta Rabin, Michael Eldar, David Castel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The effect of hypoxia on skin blood flow was examined in anesthetized rabbits during induction of various levels of hypoxia. Peripheral perfusion and oxygenation were monitoring using a combined system (LPT) composed of a laser Doppler flowmeter (LDF), a photoplatysmograph (PPG), and a transcutaneous oxygen tension monitor (tc-PO2). Central blood parameters (PaO2, HCO3-, SaO2, pH, and lactate) were measured concomitantly throughout the experiment. A continuous decline was found in both peripheral and central values, depending on the severity of the hypoxia. The results clearly indicate that monitoring peripheral indices with the LPT system enables monitoring changes of vital blood parameters during hypoxia. The system has clinical potential for sensitive and noninvasive monitoring of vital variables during medical procedures in clinics, as well as for homecare for patients with respiratory diseases. Minimizing the system may be useful in various conditions of exposure to low oxygen levels, such as during mountain climbing.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalRespiratory Physiology and Neurobiology
StatePublished - 5 Sep 2015


  • Hypoxia
  • Laser Doppler flowmetry
  • Noninvasive monitoring
  • Peripheral microcirculation
  • Photoplatysmograph
  • Transcutaneous oxygen tension


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