Non‐Hodgkin's lymphoma complicating acute lymphoblastic leukemia in remission

Eitan Friedman, Isaac Ben‐Bassat*, George Kende, Albert J. Behar, Bracha Ramot

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Second malignancies occurring in patients cured of childhood acute lymphoblastic leukemia (ALL) are rare but increasingly recognized. There are only three reported cases of non‐Hodgkin's lymphoma complicating ALL in remission. We report here another case of B‐cell‐type large‐cell lymphoma, presenting in the uterus of a 24‐year‐old woman, 16.5 years after the diagnosis of ALL was made. Although immune markers of the ALL were not available, it was thought to be unlikely that the second malignancy was a relapse of the original tumor. Due to the long latency period and the minimal exposure to alkylating agents, the role of chemotherapy seems to be insignificant in this case. The development of a second malignancy could be a manifestation of the basic susceptibility to cancer.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
JournalMedical and Pediatric Oncology
Issue number2
StatePublished - 1988


  • B‐cell‐type large‐cell lymphoma
  • acute lymphoblastic leukemia
  • latency period
  • second malignancy


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