Non steroidal anti-inflammatory drugs and inflammatory bowel disease

Amir Klein, Rami Eliakim*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Inflammatory Bowel Diseases (IBD) are an immune mediated chronic or relapsing disorders of the gastrointestinal (GI) tract. IBD is characterized by a chronic intestinal inflammatory process with various components contributing to the pathogenesis of the disease including environmental factors such as smoking or use of Non Steroidal Anti-Inflammatory Drugs (NSAIDS). NSAIDS are among the most commonly used medications for the treatment of various inflammatory conditions. The main factor limiting NSAIDS use is the concern for the development of gastrointestinal toxicity including mucosal injury. A possible association between the use of NSAIDS and the onset or relapse of IBD has been repeatedly suggested. This article will review the current concepts and evidence of the relationship between IBD and NSAIDS.

Original languageEnglish
Pages (from-to)1084-1092
Number of pages9
Issue number4
StatePublished - 2010
Externally publishedYes


  • Crohn's
  • IBD
  • NSAIDs
  • Ulcerative colitis


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