Non-replicating mucosal and systemic vaccines: Quantitative and qualitative differences in the Ag-specific CD8+ T cell population in different tissues

Udi Qimron, Lada Paul, Erez Bar-Haim, Noga Bloushtain, Lea Eisenbach, Herman F. Staats, Angel Porgador*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Directed dissemination of Ag-specific CD8+ T cells to infected organs or cancerous tissues is a prerequisite for optimal immunotherapy. Ag-specific CD8+ T cells were quantitated in systemic and mucosal tissues after nasal, rectal, or cutaneous immunization with CTL epitope peptide and the adjuvant cholera toxin (CT). Mucosal and cutaneous immunization induced Ag-specific CD8+ lymphocytes that were detectable in both mucosal and systemic compartments, suggesting a less strict distribution pattern than that known for B cells. However, optimal localization, activation and phenotype of these cells correlated with the route of immunization. In accordance with this observation, protection against a mucosal challenge with a virus expressing the CTL epitope was superior in mucosally-immunized animals.

Original languageEnglish
Pages (from-to)1390-1394
Number of pages5
JournalVaccine
Volume22
Issue number11-12
DOIs
StatePublished - 29 Mar 2004
Externally publishedYes

Funding

FundersFunder number
Israel’s Ministry of Science
Kreitman Foundation in BGU
Israel Cancer Research Fund
Maryland Ornithological Society
German Cancer Research Center
United States-Israel Binational Science Foundation
Israel Cancer Association
Israel Science Foundation

    Keywords

    • CT
    • CTL
    • Cancer
    • Mucosal/systemic vaccines
    • Non-replicating
    • Virus

    Fingerprint

    Dive into the research topics of 'Non-replicating mucosal and systemic vaccines: Quantitative and qualitative differences in the Ag-specific CD8+ T cell population in different tissues'. Together they form a unique fingerprint.

    Cite this