Non-random chromosomal aberrations in a complex leukaemic clone of a Bloom's syndrome patient

Fiorella Shabtai, U. H. Lewinski, A. Meroz, Dvora Klar, M. Djaldetti, I. Halbrecht

Research output: Contribution to journalArticlepeer-review

Abstract

Bloom's syndrome is one of the congenital disorders known to have increased frequency of acute leukaemia. The complex cytogenetic findings in the leukaemic cells of a 39-year-old male with Bloom's syndrome are described. These included a translocation t(7;17), missing 7q and 17p, a reciprocal translocation t(4;22); del 3q, del 8q22, del 20q, missing 12 and missing Y. In the same patient a missing Y had been noted 10 years previously in 15% of his peripheral blood lymphocytes.

Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalHuman Genetics
Volume80
Issue number3
DOIs
StatePublished - Nov 1988

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