Non-Invasive Lung IMPEDANCE-Guided Preemptive Treatment in Chronic Heart Failure Patients: A Randomized Controlled Trial (IMPEDANCE-HF Trial)

Michael Kleiner Shochat*, Avraham Shotan, David S. Blondheim, Mark Kazatsker, Iris Dahan, Aya Asif, Yoseph Rozenman, Ilia Kleiner, Jean Marc Weinstein, Aaron Frimerman, Lubov Vasilenko, Simcha R. Meisel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Background Previous investigations have suggested that lung impedance (LI)-guided treatment reduces hospitalizations for acute heart failure (AHF). A single-blind 2-center trial was performed to evaluate this hypothesis ( Methods The study population included 256 patients from 2 medical centers with chronic heart failure and left ventricular ejection fraction ≤35% in New York Heart Association class II-IV, who were admitted for AHF within 12 months before recruitment. Patients were randomized to a control group treated by clinical assessment and a monitored group whose therapy was also assisted by LI, and followed for at least 12 months. Noninvasive LI measurements were performed with a new high-sensitivity device. Patients, blinded to their assignment group, were scheduled for monthly visits in the outpatient clinics. The primary efficacy endpoint was AHF hospitalizations; the secondary endpoints were all-cause hospitalizations and mortality. Results There were 67 vs 158 AHF hospitalizations during the first year (P < .001) and 211 vs 386 AHF hospitalizations (P < .001) during the entire follow-up among the monitored patients (48 ± 32 months) and control patients (39 ± 26 months, P = .01), respectively. During the follow-up, there were 42 and 59 deaths (hazard ratio 0.52, 95% confidence interval 0.35–0.78, P = .002) with 13 and 31 of them resulting from heart failure (hazard ratio 0.30, 95% confidence interval 0.15–0.58 P < .001) in the monitored and control groups, respectively. The incidence of noncardiovascular death was similar. Conclusion Our results seem to validate the concept that LI-guided preemptive treatment of chronic heart failure patients reduces hospitalizations for AHF as well as the incidence of heart failure, cardiovascular, and all-cause mortality.

Original languageEnglish
Pages (from-to)713-722
Number of pages10
JournalJournal of Cardiac Failure
Issue number9
StatePublished - 1 Sep 2016


  • Acute heart failure
  • chronic heart failure
  • lung impedance
  • monitoring heart failure


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