Non-invasive continuous imaging of drug release from soy-based skin equivalent using wide-field interferometry

Haniel Gabai, Maya Baranes-Zeevi, Meital Zilberman, Natan T. Shaked

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We propose an off-axis interferometric imaging system as a simple and unique modality for continuous, non-contact and non-invasive wide-field imaging and characterization of drug release from its polymeric device used in biomedicine. In contrast to the current gold-standard methods in this field, usually based on chromatographic and spectroscopic techniques, our method requires no user intervention during the experiment, and only one test-tube is prepared. We experimentally demonstrate imaging and characterization of drug release from soy-based protein matrix, used as skin equivalent for wound dressing with controlled anesthetic, Bupivacaine drug release. Our preliminary results demonstrate the high potential of our method as a simple and low-cost modality for wide-field imaging and characterization of drug release from drug delivery devices.

Original languageEnglish
Title of host publicationOptical Methods for Inspection, Characterization, and Imaging of Biomaterials
PublisherSPIE
ISBN (Print)9780819496089
DOIs
StatePublished - 2013
EventOptical Methods for Inspection, Characterization, and Imaging of Biomaterials - Munich, Germany
Duration: 15 May 201316 May 2013

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume8792
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceOptical Methods for Inspection, Characterization, and Imaging of Biomaterials
Country/TerritoryGermany
CityMunich
Period15/05/1316/05/13

Keywords

  • Drug release
  • drug delivery devices
  • holography
  • interferometry

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