Non-functioning pituitary adenomas

Yona Greenman*, Naftali Stern

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Non-functioning pituitary tumours are mostly of gonadotroph cell origin and are devoid of humoral hypersecretory syndromes. They are usually large at the time of diagnosis, commonly presenting with headaches, visual field defects and hypopituitarism. Trans-sphenoidal surgery remains the treatment of choice for rapid decompression of neighbouring structures, often bringing to normalisation or improvement of visual and pituitary function. The management of patients with postoperative residual tumours is still a matter of debate and may include observation alone, the use of dopamine agonists or radiation therapy. There are no controlled or comparative studies of the available therapeutic options; therefore, recommendations are not evidence based. Patients need long-term follow-up for the detection and treatment of hypopituitarism, visual dysfunction and tumour growth that may develop over time.

Original languageEnglish
Pages (from-to)625-638
Number of pages14
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Issue number5
StatePublished - Oct 2009
Externally publishedYes


  • gonadotroph
  • non-functioning
  • pituitary adenoma


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