Non-erythroid effects of erythropoietin: Are neutrophils a target?

Maayan Avneon, Lilach Lifshitz, Odelia Katz, Sara Prutchi-Sagiv, Max Gassmann, Moshe Mittelman, Drorit Neumann

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously shown that erythropoietin (EPO) potentiates the immune response. Analysis of various possible cellular mediators was performed on EPO-injected mice and transgenic mice overexpressing human EPO (tg6). Here we present our studies on neutrophils, peritoneal (casein induced), and from the peripheral blood, spleen and bone marrow. Neutrophil counts were elevated in peripheral blood and spleens of the tg6 mice, yet, no other EPO-associated effects were detected in the count and function of the different neutrophil populations. Hence, neutrophils are probably not mediators of the EPO immunological effects, although their counts may be affected by extreme EPO levels.

Original languageEnglish
Pages (from-to)1430-1432
Number of pages3
JournalLeukemia Research
Volume33
Issue number10
DOIs
StatePublished - Oct 2009

Keywords

  • Erythropoietin
  • Inflammation
  • Murine models
  • Neutrophils

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