TY - JOUR
T1 - Non-coding RNAs as the bridge between epigenetic mechanisms, lineages and domains of life
AU - Sela, Mor
AU - Kloog, Yoel
AU - Rechavi, Oded
PY - 2014/6/1
Y1 - 2014/6/1
N2 - Many cases of heritable environmental responses have been documented but the underlying mechanisms are largely unknown. Recently, inherited RNA interference has been shown to act as a multigenerational genome surveillance apparatus. We suggest that inheritance of regulatory RNAs is at the root of many other epigenetic phenomena, the trigger that induces other epigenetic mechanisms, such as the depositing of histone modifications and DNA methylation. In addition, we explore the possibility that interacting organisms influence each other's transcriptomes by exchanging heterologous non-coding RNAs.
AB - Many cases of heritable environmental responses have been documented but the underlying mechanisms are largely unknown. Recently, inherited RNA interference has been shown to act as a multigenerational genome surveillance apparatus. We suggest that inheritance of regulatory RNAs is at the root of many other epigenetic phenomena, the trigger that induces other epigenetic mechanisms, such as the depositing of histone modifications and DNA methylation. In addition, we explore the possibility that interacting organisms influence each other's transcriptomes by exchanging heterologous non-coding RNAs.
UR - http://www.scopus.com/inward/record.url?scp=84901495661&partnerID=8YFLogxK
U2 - 10.1113/jphysiol.2014.273045
DO - 10.1113/jphysiol.2014.273045
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AN - SCOPUS:84901495661
SN - 0022-3751
VL - 592
SP - 2369
EP - 2373
JO - Journal of Physiology
JF - Journal of Physiology
IS - 11
ER -