Non-coding RNAs as the bridge between epigenetic mechanisms, lineages and domains of life

Mor Sela, Yoel Kloog, Oded Rechavi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Many cases of heritable environmental responses have been documented but the underlying mechanisms are largely unknown. Recently, inherited RNA interference has been shown to act as a multigenerational genome surveillance apparatus. We suggest that inheritance of regulatory RNAs is at the root of many other epigenetic phenomena, the trigger that induces other epigenetic mechanisms, such as the depositing of histone modifications and DNA methylation. In addition, we explore the possibility that interacting organisms influence each other's transcriptomes by exchanging heterologous non-coding RNAs.

Original languageEnglish
Pages (from-to)2369-2373
Number of pages5
JournalJournal of Physiology
Volume592
Issue number11
DOIs
StatePublished - 1 Jun 2014

Funding

FundersFunder number
Fonds National de la Reserche Luxembourg335624

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