Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis

Graciela L. Boccaccio; Felix Mor; Lawrence Steinman

doi:10.1093/intimm/11.2.289

Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis

Graciela L. Boccaccio, Felix Mor, Lawrence Steinman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Regulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine production in vivo. We demonstrate here that injection of plasmid DNA can suppress the prototypic T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis, by inducing IFN-γ.

Original language	English
Pages (from-to)	289-296
Number of pages	8
Journal	International Immunology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1093/intimm/11.2.289
State	Published - 1999
Externally published	Yes

Keywords

Autoimmunity
Cytokines
Experimental autoimmune encephalomyelitis
Gene therapy
Multiple sclerosis
Vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/intimm/11.2.289

Cite this

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title = "Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis",

abstract = "Regulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine production in vivo. We demonstrate here that injection of plasmid DNA can suppress the prototypic T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis, by inducing IFN-γ.",

keywords = "Autoimmunity, Cytokines, Experimental autoimmune encephalomyelitis, Gene therapy, Multiple sclerosis, Vaccination",

author = "Boccaccio, {Graciela L.} and Felix Mor and Lawrence Steinman",

year = "1999",

doi = "10.1093/intimm/11.2.289",

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AU - Boccaccio, Graciela L.

AU - Mor, Felix

AU - Steinman, Lawrence

PY - 1999

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N2 - Regulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine production in vivo. We demonstrate here that injection of plasmid DNA can suppress the prototypic T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis, by inducing IFN-γ.

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KW - Autoimmunity

KW - Cytokines

KW - Experimental autoimmune encephalomyelitis

KW - Gene therapy

KW - Multiple sclerosis

KW - Vaccination

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DO - 10.1093/intimm/11.2.289

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C2 - 10069427

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SN - 0953-8178

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EP - 296

JO - International Immunology

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ER -

Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis

Abstract

Keywords

UN SDGs

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